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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제3호
- 발행연도
- 2005.1
- 수록면
- 660 - 664 (5page)
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초록· 키워드
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We have previously isolated specific RNA aptamerswith high affinity against the helicase domain of hepatitisC virus (HCV) nonstructural protein 3 (NS3). The RNAaptamers competitively and efficiently inhibited the helicaseactivity, partially impeding HCV replicon replication in humanhepatocarcinoma cells. In this study, the RNA aptamers weretested for binding to the HCV NS3 proteins in eukaryoticcells, using a yeast three-hybrid system. The aptamers werethen recognized by the HCV NS3 proteins when expressed inthe cells, while the antisense sequences of the aptamers werenot. These results suggest that the in vitro selected RNAaptamers can also specifically bind to the target proteins invivo. Consequently, they could be potentially utilized as anti-HCV lead compounds.
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참고문헌 (18)
참고문헌 신청
A / 2002 / Selection of RNA aptamers that are specificand high-affinity ligands of the hepatitis C virus RNAdependentRNA polymerase : 3688 ~ 3696
Baek / 2003 / lacz- and aph-basedreporter vectors for in vivo expression technology 13 : 872 ~ 880
Cassiday / 2001 / In vivo recognitionof an RNA aptamer by its transcription factor target 40 : 2433 ~ 2438
Dubuisson / 2004 / Structural biology of hepatitis C virus 39 : 5 ~ 39 19
Ellington / 1990 / In vitro selection ofRNA molecules that bind specific ligands : 818 ~ 346 822
Baek / 2003 / lacz- and aph-basedreporter vectors for in vivo expression technology 13 : 872 ~ 880
Cassiday / 2001 / In vivo recognitionof an RNA aptamer by its transcription factor target 40 : 2433 ~ 2438
Dubuisson / 2004 / Structural biology of hepatitis C virus 39 : 5 ~ 39 19
Ellington / 1990 / In vitro selection ofRNA molecules that bind specific ligands : 818 ~ 346 822
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