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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제9호
- 발행연도
- 2015.1
- 수록면
- 1,532 - 1,536 (5page)
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초록· 키워드
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To investigate the memory-enhancing effect of lactic acid bacteria, we selected the probiotic mixture KF, which consisted of Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (1 × 1011 CFU/g of each strain), and investigated its antilipidemic and memoryenhancing effects in aged Fischer 344 rats. KF (1 × 1010 CFU/rat/day), which was administered orally once a day (6 days per week) for 8 weeks, significantly inhibited age-dependent increases of blood triglyceride and reductions of HDL cholesterol (p < 0.05). KF restored agereduced spontaneous alternation in the Y-maze task to 94.4% of that seen in young rats (p < 0.05). KF treatment slightly, but not significantly, shortened the escape latency daily for 4 days. Oral administration of KF restored age-suppressed doublecortin and brain-derived neurotrophic factor expression in aged rats. Orally administered KF suppressed the expression of p16, p53, and cyclooxygenase-2, the phosphorylation of Akt and mTOR, and the activation of NF-κB in the hippocampus of the brain. These findings suggest that KF may ameliorate age-dependent memory deficit and lipidemia by inhibiting NF-κB activation.
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참고문헌 (21)
참고문헌 신청
Bubici C / 2006 / Mutual crosstalk between reactive oxygen species and nuclear factorkappa B: molecular basis and biological significance / Oncogene 25 : 6731 ~ 6748
Cammarota G / 2014 / Gut microbiota modulation: probiotics, antibiotics or fecal microbiota transplantation? / Intern. Emerg. Med 9 : 365 ~ 373
Chapple IL / 1997 / Reactive oxygen species and antioxidants in inflammatory diseases / J. Clin. Periodontol 24 : 287 ~ 296
Chung H / 2011 / Molecular inflammation as an underlying mechanism of the aging process and age-related diseases / J. Dent. Res 90 : 830 ~ 840
Craft S / 2005 / Insulin resistance syndrome and Alzheimer’s disease: age- and obesity-related effects on memory, amyloid, and inflammation / Neurobiol. Aging 26 : 65 ~ 69
Cammarota G / 2014 / Gut microbiota modulation: probiotics, antibiotics or fecal microbiota transplantation? / Intern. Emerg. Med 9 : 365 ~ 373
Chapple IL / 1997 / Reactive oxygen species and antioxidants in inflammatory diseases / J. Clin. Periodontol 24 : 287 ~ 296
Chung H / 2011 / Molecular inflammation as an underlying mechanism of the aging process and age-related diseases / J. Dent. Res 90 : 830 ~ 840
Craft S / 2005 / Insulin resistance syndrome and Alzheimer’s disease: age- and obesity-related effects on memory, amyloid, and inflammation / Neurobiol. Aging 26 : 65 ~ 69
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