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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제1호
- 발행연도
- 2018.1
- 수록면
- 175 - 179 (5page)
이용수
초록· 키워드
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In a preliminary study, Lactobacillus plantarum C29 was found to suppress 2,4,6- trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered Lactobacillus plantarum C29 attenuated TNBS-induced memory impairment in mice in the Y-maze, noble object, and passive avoidance task tests. C29 treatment increased TNBS-suppressed hippocampal brain-derived neurotrophic factor expression and inhibited TNBS-induced hippocampal NF-κB activation and blood LPS levels. Moreover, C29 restored the TNBSdisturbed gut microbiota composition. These findings suggest that C29 can alleviate memory impairment presumably by restoring the gut microbiota composition.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Grenham S / 2011 / Brain-gutmicrobe communication in health and disease / Front. Physiol. 2:94
Fung TC / 2017 / Interactions between the microbiota, immune and nervous systems in health and disease / Nat. Neurosci. 20:145~155
Mayer EA / 2015 / Gut/brain axis and the microbiota / J. Clin. Invest. 125:926~938
Diaz Heijtz R / 2011 / Normal gut microbiota modulates brain development and behavior / Proc. Natl. Acad. Sci. USA 108:3047~3052
Jang SE / 2017 / Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice / Mucosal Immunol
Fung TC / 2017 / Interactions between the microbiota, immune and nervous systems in health and disease / Nat. Neurosci. 20:145~155
Mayer EA / 2015 / Gut/brain axis and the microbiota / J. Clin. Invest. 125:926~938
Diaz Heijtz R / 2011 / Normal gut microbiota modulates brain development and behavior / Proc. Natl. Acad. Sci. USA 108:3047~3052
Jang SE / 2017 / Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice / Mucosal Immunol
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