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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제5호
- 발행연도
- 2017.1
- 수록면
- 878 - 895 (18page)
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초록· 키워드
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Phosphorylation, a critical mechanism in biological systems, is estimated to be indispensable for about 30% of key biological activities, such as cell cycle progression, migration, and division. It is synergistically balanced by kinases and phosphatases, and any deviation from this balance leads to disease conditions. Pathway or biological activity-based abnormalities in phosphorylation and the type of involved phosphatase influence the outcome, and cause diverse diseases ranging from diabetes, rheumatoid arthritis, and numerous cancers. Protein tyrosine phosphatases (PTPs) are of prime importance in the process of dephosphorylation and catalyze several biological functions. Abnormal PTP activities are reported to result in several human diseases. Consequently, there is an increased demand for potential PTP inhibitory small molecules. Several strategies in structure-based drug designing techniques for potential inhibitory small molecules of PTPs have been explored along with traditional drug designing methods in order to overcome the hurdles in PTP inhibitor discovery. In this review, we discuss druggable PTPs and structure-based virtual screening efforts for successful PTP inhibitor design.
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참고문헌 (22)
참고문헌 신청
Alonso A / 2004 / Protein tyrosine phosphatases in the human genome / Cell 117 : 699 ~ 711
Byrum CA / 2006 / Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions / Dev. Biol 300
Cousin C / 2013 / Protein-serine/threonine/tyrosine kinases in bacterial signaling and regulation / FEMS Microbiol. Lett 346 : 11 ~ 19
Danishuddin M / 2014 / Structure-based screening of inhibitors against KPC-2: designing potentia
Demers JP / 2011 / Progress in correlation spectroscopy at ultra-fast magic-angle spinning:basic building blocks and complex experiments for the study of protein structure a
Byrum CA / 2006 / Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions / Dev. Biol 300
Cousin C / 2013 / Protein-serine/threonine/tyrosine kinases in bacterial signaling and regulation / FEMS Microbiol. Lett 346 : 11 ~ 19
Danishuddin M / 2014 / Structure-based screening of inhibitors against KPC-2: designing potentia
Demers JP / 2011 / Progress in correlation spectroscopy at ultra-fast magic-angle spinning:basic building blocks and complex experiments for the study of protein structure a
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