지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Protein tyrosine phosphatases (PTPs) dephosphorylate their target proteins in various cell signaling processes and their dephosphorylation activities are associated with cancers, neurological disorders, and diabetes. Although PTPs are considered as promising drug targets, no PTP-targeting drugs are currently on the market. To understand inhibitor binding to PTP proteins, we determined crystal structure of the complex between DUSP15, a member of PTP family and its inhibitor. In the complex structure, extra electron density observed near the active site pocket was fitted to the inhibitor structure. The inhibitor binding site does not overlap the phosphate-binding active site. The novel inhibitor binding interactions involving the P-, D-, and β3-β4 loops indicate an allosteric inhibition mechanism of the inhibitor.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Adams, P. D. / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr D Biol Crystallogr 66:213~221
Alonso, A. / 2004 / VHY, a novel myristoylated testisrestricted dual specificity protein phosphatase related to VHX / J Biol Chem 279:32586~32591
Alonso, A. / 2016 / The extended human PTPome : a growing tyrosine phosphatase family / FEBS J 283:2197~2201
Andersen, J. N. / 2001 / Structural and evolutionary relationships among protein tyrosine phosphatase domains / Mol Cell Biol 21:7117~7136
Bermudez, O. / 2010 / The dual-specificity MAP kinase phosphatases: critical roles in development and cancer / Am J Physiol Cell Physiol 299:c189~202
Alonso, A. / 2004 / VHY, a novel myristoylated testisrestricted dual specificity protein phosphatase related to VHX / J Biol Chem 279:32586~32591
Alonso, A. / 2016 / The extended human PTPome : a growing tyrosine phosphatase family / FEBS J 283:2197~2201
Andersen, J. N. / 2001 / Structural and evolutionary relationships among protein tyrosine phosphatase domains / Mol Cell Biol 21:7117~7136
Bermudez, O. / 2010 / The dual-specificity MAP kinase phosphatases: critical roles in development and cancer / Am J Physiol Cell Physiol 299:c189~202
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