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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제3호
- 발행연도
- 2017.1
- 수록면
- 584 - 590 (7page)
이용수
초록· 키워드
오류제보하기
Ginkgo biloba extract (EGb 761) has been widely used clinically to reduce myocardial ischemia reperfusion injury (MIRI). Microvascular endothelial cells (MVECs) may be a proper cellular model in vitro for the effect and mechanism study against MIRI. However, the protective effect of EGb 761 on MVECs resisting hypoxia/reoxygenation (H/R) injury is little reported. In this study, H/R-injured MVECs were treated with EGb 761, and then the cell viability, apoptosis, ROS production, SOD activity, caspase-3 activity, and protein level of ATM, γ-H2AX, p53, and Bax were measured. ATM siRNA was transfected to study the changes of protein in the ATM pathway. EGb 761 presented protective effect on H/R-injured MVECs, with decreasing cell death, apoptosis, and ROS, and elevated SOD activity. Next, EGb 761 could inhibit H/R-induced ATM, γ-H2AX, p53, and Bax in a dose-dependent manner. Moreover, ATM siRNA also could inhibit H/R-induced ATM, γ-H2AX, p53, and Bax. Overall, these findings verify that EGb 761 protects cardiac MVECs from H/R injury, and for the first time, illustrate the influence on the ATM pathway and apoptosis by EGb 761 via dampening ROS.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aird WC. / 2007 / Phenotypic heterogeneity of the endothelium:I. Structure, function, and mechanisms / Circ. Res 100 : 158 ~ 173
Bencokova Z / 2009 / ATM activation and signaling under hypoxic conditions / Mol. Cell. Biol 29 : 526 ~ 537
Burma S / 2001 / ATM phosphorylates histone H2AX in response to DNA double-strand breaks / J. Biol. Chem 276 : 42462 ~ 42467
Chandrasekaran K / 2002 / Bilobalide, a c omponent of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced
Chiang JH / 2013 / Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulate
Bencokova Z / 2009 / ATM activation and signaling under hypoxic conditions / Mol. Cell. Biol 29 : 526 ~ 537
Burma S / 2001 / ATM phosphorylates histone H2AX in response to DNA double-strand breaks / J. Biol. Chem 276 : 42462 ~ 42467
Chandrasekaran K / 2002 / Bilobalide, a c omponent of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced
Chiang JH / 2013 / Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulate
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