지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 261 - 267 (7page)
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초록· 키워드
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Objective Noninvasive prenatal detection of trisomy 21 (T21) has been achieved by measuring the ratio of two alleles of a single nucleotide polymorphism in circulating placenta specific 4 (PLAC4) mRNA in maternal plasma with a few assays in recent years. Our research is to explore the variations of PLAC4 mRNA expression level in maternal plasma with normal pregnancies in second trimester, which can provide pregnant women deeper insights with suitable detection period for the non-invasive prenatal detection of T21.
Methods We measured a serial plasma PLAC4 mRNA concentrations weekly from the same 25 singleton normal pregnant women. We recruited maternal plasma samples from 45 singleton pregnant women , comprising of 25 euploid pregnancies (control group; range, 17 to 21 weeks) and 20 T21 pregnancies (T21 group; range, 19 to 24 weeks). With the application of reverse transcription polymerase chain reaction, we achieved an insight of PLAC4 mRNA expression levels in maternal plasma during second trimester with euploid pregnancies.
Results Among the control group, the levels of PLAC4 mRNA expression in the gestation of 17 to 18 weeks were significantly less than those in the gestation of 18 to 21 weeks (P<0.05). The average PLAC4 mRNA concentration of the normal pregnant women was not higher than that of the T21 group (P>0.05).
Conclusion The PLAC4 mRNA showed a higher level of expression in the gestation of 18 to 21 weeks with an euploid pregnancy of pregnant women. We also found that there was no significant difference in plasma PLAC4 mRNA concentration between the normal and the T21 pregnancies in second trimester.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alfirevic Z. / 2003 / Amniocentesis and chorionic villus sampling for prenatal diagnosis / Cochrane Database Syst Rev : CD003252 ~
Breathnach FM. / 2007 / Screening for aneuploidy in first and second trimesters : is there an optimal paradigm? / Curr Opin Obstet Gynecol 19 : 176 ~ 182
Conti A. / 2007 / Altered
Kido S. / 1993 / D21S418E identifies a cAMP-regulated gene located on chromosome 21q22. 3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells / Geno
Kroh EM. / 2010 / Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR(qRT-PCR) / Methods 50 : 298 ~ 301
Breathnach FM. / 2007 / Screening for aneuploidy in first and second trimesters : is there an optimal paradigm? / Curr Opin Obstet Gynecol 19 : 176 ~ 182
Conti A. / 2007 / Altered
Kido S. / 1993 / D21S418E identifies a cAMP-regulated gene located on chromosome 21q22. 3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells / Geno
Kroh EM. / 2010 / Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR(qRT-PCR) / Methods 50 : 298 ~ 301
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