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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 38 - 47 (10page)
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초록· 키워드
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ObjectiveThe aim of this study was to investigate the prevalence of abnormal vaginal microorganisms in pregnant women according to trimester, and to determine whether the presence of abnormal vaginal colonization is associated with higher risk of miscarriage or preterm delivery. Furthermore, we analyzed delivery outcomes according to individual microorganism species. MethodsWe included pregnant women who underwent vaginal culture during routine prenatal check-up between January 2011 and June 2016. We compared delivery outcomes according to the presence or absence of abnormal vaginal flora grouped by trimester. ResultsThis study included 593 singleton pregnancies. We classified participants into 3 groups, according to the trimester in which vaginal culture was performed; 1st trimester (n=221), 2nd trimester (n=138), and 3rd trimester (n=234). Abnormal vaginal colonization rate significantly decreased with advancing trimester of pregnancy (21.7% for 1st, 21.0% for 2nd, 14.5% for 3rd; P=0.048). Abnormal vaginal colonization detected in the 2nd trimester but not in 1st trimester was associated with a significant increase in preterm delivery before 28 weeks of gestation (6.9% vs. 0%; P=0.006). Among abnormal vaginal flora isolated in the 2nd trimester, the presence of Klebsiella pneumonia was identified as significant microorganism associated with preterm delivery before 28 weeks of gestation (50% vs. 0.7% for K. pneumonia; P=0.029). ConclusionThere is an association between abnormal vaginal colonization detected in the 2nd trimester and preterm delivery before 28 weeks. K. pneumonia has been identified as the likely causative microorganisms.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Aagaard K / 2012 / A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy / PLoS One 7:e36466
McLean NW / 2000 / Characterisation and selection of a Lactobacillus species to re-colonise the vagina of women with recurrent bacterial vaginosis / J Med Microbiol 49:543~552
Martin HL / 1999 / Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition / J Infect Dis 180:1863~1868
Hay PE / 1994 / Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage / BMJ 308:295~298
Donati L / 2010 / Vaginal microbial flora and outcome of pregnancy / Arch Gynecol Obstet 281:589~600
McLean NW / 2000 / Characterisation and selection of a Lactobacillus species to re-colonise the vagina of women with recurrent bacterial vaginosis / J Med Microbiol 49:543~552
Martin HL / 1999 / Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition / J Infect Dis 180:1863~1868
Hay PE / 1994 / Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage / BMJ 308:295~298
Donati L / 2010 / Vaginal microbial flora and outcome of pregnancy / Arch Gynecol Obstet 281:589~600
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