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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 198 - 204 (7page)
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Background: Establishment of trimester- and assay-specific reference intervals for every population is recommended. The aim of this study was to establish a trimester- and assay-specific reference interval for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in Korean pregnant women.
Methods: From April 2012 to December 2012, 531 pregnant women receiving prenatal care and 238 age-matched, non-pregnant women were enrolled in this study. After excluding patients with pregnancy-associated complications or thyroid-specific autoantibody, 465 pregnant and 206 non-pregnant women were included. Non-parametric analysis (2.5-97.5th percentile) was performed to determine the reference interval. Levels of TSH and FT4 were determined by electrochemiluminescence immunoassay (Elecsys thyroid tests, Roche Diagnostics, Germany).
Results: The TSH reference intervals were 0.01-4.10, 0.01-4.26, and 0.15-4.57 mIU/L for the first, second, and third trimester, respectively. From the first trimester to the third trimester, the median TSH levels showed a significantly increasing trend (P<0.0001). The FT4 reference intervals were 0.83-1.65, 0.71-1.22, and 0.65-1.13 ng/dL for the first, second, and third trimester, respectively, showing a significantly decreasing trend (P<0.0001).
Conclusions: Establishing trimester-specific reference intervals in pregnant women is essential for accurate assessment of thyroid function. Our population-specific and method-specific reference intervals will be useful for screening Korean pregnant women for thyroid disease.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abalovich M / 2002 / Overt and subclinical hypothyroidism complicating pregnancy / Thyroid 12 : 63 ~ 68
Allan WC / 2000 / Maternal thyroid deficiency and pregnancy complications: implications for population screening / J Med Screen 7 : 127 ~ 130
Azizi F / 2013 / Establishment of the trimester-specific reference range for free thyroxine index / Thyroid 23 : 354 ~ 359
Baloch Z / 2003 / Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease / Thyroid 13 : 3 ~ 126
Casey BM / 2005 / Subclinical hypothyroidism and pregnancy outcomes / Obstet Gynecol 105 : 239 ~ 245
Allan WC / 2000 / Maternal thyroid deficiency and pregnancy complications: implications for population screening / J Med Screen 7 : 127 ~ 130
Azizi F / 2013 / Establishment of the trimester-specific reference range for free thyroxine index / Thyroid 23 : 354 ~ 359
Baloch Z / 2003 / Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease / Thyroid 13 : 3 ~ 126
Casey BM / 2005 / Subclinical hypothyroidism and pregnancy outcomes / Obstet Gynecol 105 : 239 ~ 245
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