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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제20권 제2호
- 발행연도
- 2019.1
- 수록면
- 30 - 36 (7page)
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초록· 키워드
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The occurrence of allergic disease has increased harmfully in the last few decades. Atopic dermatitis (AD) is an allergic inflammation disorder characterized by itchy, red, swollen, cracked skin. Although the pathogenesis of AD is not fully understood, it is assumed that deregulation of T-helper 1 (Th1) and T-helper 2 (Th2) immune responses, a predominance of allergen-specific IgE, and interrupted epidermal barrier function are keys to the pathogenic mechanism. Activated T helper 2 (Th2) immune function is hallmark of various allergic diseases. Oxidative stress implicated in cutaneous damage in various inflammatory skin diseases. We investigated the effect of fermented soybean (SCGB1) on the improvement of AD. Soybean fermentation was carried out using B. amyloliquefaciense SCGB1 (KCCM11964P), which is known to produce of natural antibiotics. And then, we experiment of SCGB1 and soybean powder (NC) in DNCB-induced AD model. Mice were respectively oral administration of variety dose for 14 days. As a results, it was confirmed that serum Immunoglobulin E (IgE) expression was dose-dependently decreased in SCGB1 and NC compared to negative control, and it was reduced the skin pruritus inducing factor that Interleukin-31 (IL-31) mRNA level. In addition, the inflammatory cells were infiltration in skin for histological analysis. As a result, it reduced that epidermal hyperplasia, cancellation and aveolarization compared to negative control. These results suggest that SCGB1 may be effective for prevention and treatment of AD.
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참고문헌 (17)
참고문헌 신청
Novak N / 2003 / Immune mechanisms leading to atopic dermatitis / J Allergy Clin Immunol 112:S128~S139
Tokura Y / 2010 / Extrinsic and intrinsic types of atopic dermatitis / J Dermatol Sci 58:1~7
Grewe M / 1998 / A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis / Immunol Today 19:359~361
Yamamura K / 2017 / The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31induction / Nat Commun 9:13946
Furue M / 2018 / Emerging role of interleukin-31 and interleukin-31receptor in pruritus in atopic dermatitis / Allergy 73:29~36
Tokura Y / 2010 / Extrinsic and intrinsic types of atopic dermatitis / J Dermatol Sci 58:1~7
Grewe M / 1998 / A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis / Immunol Today 19:359~361
Yamamura K / 2017 / The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31induction / Nat Commun 9:13946
Furue M / 2018 / Emerging role of interleukin-31 and interleukin-31receptor in pruritus in atopic dermatitis / Allergy 73:29~36
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