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논문 기본 정보
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- 학술저널
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제8호
- 발행연도
- 2019.1
- 수록면
- 1,316 - 1,323 (8page)
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Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging coronavirus which is zoonotic from bats and camels. Its infection in humans can be fatal especially in patients with preexisting conditions due to smoking and chronic obstructive pulmonary disease (COPD). Among the 25 proteins encoded by MERS-CoV, 5 accessory proteins seem to be involved in viral evasion of the host immune responses. Here we report that ORF4a, ORF4b, and ORF8b proteins, alone or in combination, effectively antagonize nuclear factor kappa B (NF-κB) activation. Interestingly, the inhibition of NF-κB by MERS-CoV accessory proteins was mostly at the level of pattern recognition receptors: melanoma differentiationassociated gene 5 (MDA5). ORF4a and ORF4b additively inhibit MDA5-mediated activation of NF-κB while that of retinoic acid-inducible gene 1 (RIG-I) is largely not perturbed. Of note, ORF8b was found to be a novel antagonist of MDA5-mediated NF-κB activation. In addition, ORF8b also strongly inhibits Tank-binding kinase 1 (TBK1)-mediated induction of NF-κB signaling. Taken together, MERS-CoV accessory proteins are involved in viral escape of NF- κB-mediated antiviral immune responses.
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참고문헌 (52)
참고문헌 신청
Anthony SJ / 2017 / Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus / MBio 8:e00373-17
Anthony SJ / 2017 / Global patterns in coronavirus diversity / Virus Evol 3:vex012
Banerjee A / 2019 / Interferon regulatory factor 3-mediated signaling limits Middle-East respiratory syndrome (MERS) coronavirus propagation in cells from an insectivorous bat / Viruses 11(2):E152
Goldstein SA / 2017 / Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus:recent advances / F1000Res 6:1628
Hu B / 2017 / Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus / PLoS Pathog 13:e1006698
Anthony SJ / 2017 / Global patterns in coronavirus diversity / Virus Evol 3:vex012
Banerjee A / 2019 / Interferon regulatory factor 3-mediated signaling limits Middle-East respiratory syndrome (MERS) coronavirus propagation in cells from an insectivorous bat / Viruses 11(2):E152
Goldstein SA / 2017 / Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus:recent advances / F1000Res 6:1628
Hu B / 2017 / Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus / PLoS Pathog 13:e1006698
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