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논문 기본 정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제12호
- 발행연도
- 2019.1
- 수록면
- 2,014 - 2,021 (8page)
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Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to the genus Betacoronavirus and causes severe morbidity and mortality in humans especially when infected patients have underlying diseases such as chronic obstructive pulmonary disease (COPD). Previously, we demonstrated that MERS-CoV-encoded ORF8b strongly inhibits MDA5- and RIG-I-mediated induction of the interferon beta (IFN-β) promoter activities. Here, we report that ORF8b seemed to regulate MDA5 or RIG-I differentially as protein levels of MDA5 were significantly down-regulated while those of RIG-I were largely unperturbed. In addition, ORF8b seemed to efficiently suppress phosphorylation of IRF3 at the residues of 386 and 396 in cells transfected with RIG-I while total endogenous levels of IRF3 remained largely unchanged. Furthermore, ORF8b was able to inhibit all forms of RIG-I; full-length, RIG-I-1-734, and RIG-I-1-228, the last of which contains only the CARD domains. Taken together, it is tempting to postulate that ORF8b may interfere with the CARD-CARD interactions between RIG-I and MAVS. Further detailed analysis is required to delineate the mechanisms of how ORF8b inhibits the MDA5/ RIG-I receptor signaling pathway.
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참고문헌 (57)
참고문헌 신청
Zaki AM / 2012 / Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia / N. Engl. J. Med 367:1814~1820
Corman VM / 2012 / Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction / Euro Surveill 17(39):20285
Chan JF / 2015 / Middle East respiratory syndrome coronavirus : another zoonotic betacoronavirus causing SARS-like disease / Clin. Microbiol. Rev 28:465~522
이정윤 / 2019 / Generation of Full-Length Infectious cDNA Clones of Middle East Respiratory Syndrome Coronavirus / Journal of Microbiology and Biotechnology 29(6):999~1007
van den Brand JM / 2015 / Pathogenesis of Middle East respiratory syndrome coronavirus / J. Pathol 235:175~184
Corman VM / 2012 / Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction / Euro Surveill 17(39):20285
Chan JF / 2015 / Middle East respiratory syndrome coronavirus : another zoonotic betacoronavirus causing SARS-like disease / Clin. Microbiol. Rev 28:465~522
이정윤 / 2019 / Generation of Full-Length Infectious cDNA Clones of Middle East Respiratory Syndrome Coronavirus / Journal of Microbiology and Biotechnology 29(6):999~1007
van den Brand JM / 2015 / Pathogenesis of Middle East respiratory syndrome coronavirus / J. Pathol 235:175~184
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