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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제3호
- 발행연도
- 2019.1
- 수록면
- 313 - 321 (9page)
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The purpose of this study was to prepare microcapsules encapsulating vitamin U (VU, S-methylmethionine) by complex coacervation. Multiple emulsion method was applied for encapsulating highly water-soluble VU. The composition of microcapsules was optimized using central composite design (CCD). The weight ratio of gelatin to gum arabic (X1) and the volume of oil phase (X2) were set as two independent variables to obtain the maximum weight of microcapsules (Y1) and the content of VU (Y2) in microcapsules higher than 2.5%. When the microcapsules were prepared based on the optimized composition, its actual Y1 and Y2 values were 95% of the predicted values. Morphology of microcapsules observed by the optical and the fluorescence microscopes was round shape. Scanning electron microscopy (SEM) image of internal particles also confirmed that the multiple emulsions were encapsulated in the microcapules. Mean particle size of microcapsules measured by the laser diffraction particle size analyzer was 79.17 μm. Differential scanning calorimetry (DSC) showed that VU exists in an amorphous state in the coacervate microcapsules. Thus, it can be concluded that hydrophilic VU was successfully encapsulated in the coacervate microcapsules using the multiple emulsion method, and the design of experiment (DoE) technique was useful to optimize the formulation.
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참고문헌 (27)
참고문헌 신청
Alvim ID / 2010 / Microparticles obtained by complex coacervation : influence of the type of reticulation and the drying process on the release of the core material / Ciencia Tecnol Alime 30:1069~1076
Anjum MF / 1997 / Response surface methodology : a neural network approach / Eur J Oper Res 101:65~73
Baş D / 2007 / Modeling and optimization I : Usability of response surface methodology / J Food Eng 78:836~845
Bosnea LA / 2014 / Complex coacervation as a novel microencapsulation technique to improve viability of probiotics under different stresses / Food Bioprocess Technol 7:2767~2781
Builders PF / 2008 / Preparation and evaluation of mucinated sodium alginate microparticles for oral delivery of insulin / Eur J Pharm Biopharm 70:777~783
Anjum MF / 1997 / Response surface methodology : a neural network approach / Eur J Oper Res 101:65~73
Baş D / 2007 / Modeling and optimization I : Usability of response surface methodology / J Food Eng 78:836~845
Bosnea LA / 2014 / Complex coacervation as a novel microencapsulation technique to improve viability of probiotics under different stresses / Food Bioprocess Technol 7:2767~2781
Builders PF / 2008 / Preparation and evaluation of mucinated sodium alginate microparticles for oral delivery of insulin / Eur J Pharm Biopharm 70:777~783
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