지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Objectives: The purpose of this study was to investigate the association between fracture risk and proton pump inhibitor (PPI) use to establish evidence for defining high-risk groups of fracture among PPI users. Methods: A case-control study was performed using the National Health Insurance Sample Cohort Database from January 2002 to December 2013. The cases included all incidences of major fractures identified from January 2011 to December 2013, and up to four controls were matched to each case by age, gender, osteoporosis, and Charlson comorbidity index. Conditional logistic regression was used to calculate the adjusted odds ratio (aOR) and associated 95% confidence interval (CI). Results: Overall, 14,295 cases were identified, and 63,435 controls were matched to the cases. The aOR of fractures related to the use of PPIs was 1.06 (95% CI: 1.01-1.11). There was a statistically significant association between fracture and PPI use within 3 months of the last dose, and a trend of increasing fracture risk with increasing cumulative PPI dose. The risk of fracture was significantly higher in patients who took PPIs for more than 1 year during the 2-year observation period. Conclusion: Patients who have been using PPIs for more than 1 year should be warned about the risk of fracture during or at least 3 months after discontinuing the PPI.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
van Pinxteren B / 2010 / Shortterm treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease / Cochrane Database Syst Rev (11):CD002095
Malfertheiner P / 2017 / Proton-pump inhibitors:understanding the complications and risks / Nat Rev Gastroenterol Hepatol 14(12):697~710
김종주 / 2018 / 국민건강보험 12년 표본코호트자료에 근거한 국내 프로톤펌프저해제 사용 현황 / 약 학 회 지 62(3):171~178
Health Insurance Review and Assessment Service: Healthcare Bigdata Hub / Statistics
Bhatt DL / 2008 / ACCF/ACG/AHA 2008expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents / Circulation 118:1894~1909
Malfertheiner P / 2017 / Proton-pump inhibitors:understanding the complications and risks / Nat Rev Gastroenterol Hepatol 14(12):697~710
김종주 / 2018 / 국민건강보험 12년 표본코호트자료에 근거한 국내 프로톤펌프저해제 사용 현황 / 약 학 회 지 62(3):171~178
Health Insurance Review and Assessment Service: Healthcare Bigdata Hub / Statistics
Bhatt DL / 2008 / ACCF/ACG/AHA 2008expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents / Circulation 118:1894~1909
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