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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 412 - 418 (7page)
- DOI
- 10.7783/KJMCS.2019.27.6.412
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Background: Previously, studies have observed that the leaf extract of Cotoneaster wilsonii Nakai has potent antioxidant and anti-inflammatory activites. Therefore, further research was conducted to separate the active antioxidant and anti-inflammatory compounds in the leaf of the C. wilsonii.
Methods and Results: The anti-oxidant effects were evaluated by analyzing the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, estimating the totla phenolic content (TPC) and total flavonoid content (TFC), and using reducing power assay method. The ethyl acetate (EtOAc) fraction demonstrated the highest DPPH radical scavenging activity (IC<SUB>50</SUB>; 9.69 ㎍/㎖), and the highest TPC and TFC (345.98 ㎎·GAE/g, and 74.23 ㎎·QE/g). Moreover, it indicated the highest effects on nitric oxide production. Therefore, the active compound was separated using the EtOAc fraction, determined on the basis of spectral data, and identified as (+)-catechin.
Conclusions: The first compound separated was made from the leaf of C. wilsonii was (+)-catechin, which produced potent anti-oxidant and anti-inflammatory effects.
Methods and Results: The anti-oxidant effects were evaluated by analyzing the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, estimating the totla phenolic content (TPC) and total flavonoid content (TFC), and using reducing power assay method. The ethyl acetate (EtOAc) fraction demonstrated the highest DPPH radical scavenging activity (IC<SUB>50</SUB>; 9.69 ㎍/㎖), and the highest TPC and TFC (345.98 ㎎·GAE/g, and 74.23 ㎎·QE/g). Moreover, it indicated the highest effects on nitric oxide production. Therefore, the active compound was separated using the EtOAc fraction, determined on the basis of spectral data, and identified as (+)-catechin.
Conclusions: The first compound separated was made from the leaf of C. wilsonii was (+)-catechin, which produced potent anti-oxidant and anti-inflammatory effects.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
고찰
REFFERENCE
참고문헌 (18)
참고문헌 신청
Blois MS / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181:1199~1200
Branen AL / 1975 / Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene / Journal of the American Oil Chemists’ Society 52:59~63
Green DR / 2005 / Pharmacological manipulation of cell death: Clinical applications in sight? / Journal of Clinical Investigation 115:2610~2617
Halliwell B / 1990 / The importance of free radicals and catalytic metal ions in human diseases / Molecular Aspects of Medicine 8:89~193
Kicel A / 2019 / Polyphenolic profile, antioxidant activity, and proinflammatory enzymes inhibition of leaves, flowers, bark and fruits of Cotoneaster integerrimus: A comparative study / Phytochemisty Letters 30:349~355
Branen AL / 1975 / Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene / Journal of the American Oil Chemists’ Society 52:59~63
Green DR / 2005 / Pharmacological manipulation of cell death: Clinical applications in sight? / Journal of Clinical Investigation 115:2610~2617
Halliwell B / 1990 / The importance of free radicals and catalytic metal ions in human diseases / Molecular Aspects of Medicine 8:89~193
Kicel A / 2019 / Polyphenolic profile, antioxidant activity, and proinflammatory enzymes inhibition of leaves, flowers, bark and fruits of Cotoneaster integerrimus: A comparative study / Phytochemisty Letters 30:349~355
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