지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 225 - 232 (8page)
이용수
초록· 키워드
오류제보하기
Innate lymphoid cells (ILCs) are key players during an immune response at the mucosal surfaces, such as lung, skin, and gastrointestinal tract. Giardia lamblia is an extracellular protozoan pathogen that inhabits the human small intestine. In this study, ILCs prepared from the lamina propria of mouse small intestine were incubated with G. lamblia trophozoites. Transcriptional changes in G. lamblia-exposed ILCs resulted in identification of activation of several immune pathways. Secretion of interleukin (IL)-17A, IL-17F, IL-1β, and interferon-γ was increased, whereas levels of IL-13, IL-5, and IL-22, was maintained or reduced upon exposure to G. lamblia. Goup 3 ILC (ILC3) was found to be dominant amongst the ILCs, and increased significantly upon co-cultivation with G. lamblia trophozoites. Oral inoculation of G. lamblia trophozoites into mice resulted in their presence in the small intestine, of which, the highest number of parasites was detected at the 5 days-post infection. Increased ILC3 was observed amongst the ILC population at the 5 days-post infection. These findings indicate that ILC3 from the lamina propria secretes IL-17 in response to G. lamblia, leading to the intestinal pathology observed in giardiasis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
Kraft MR / 2017 / Giardia's epithelial cell interaction in vitro : mimicking asymptomatic infection / Front Cell Infect Microbiol 7:421
Fink MY / 2017 / The intersection of immune responses, microbiota, and pathogenesis in giardiasis / Trends Parasitol 33:901~913
Eckmann L / 2003 / Mucosal defense against Giardia / Parasite Immunol 25:259~270
Eckmann L / 2000 / Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia / J Immunol 1643:1478~1487
Stadelmann B / 2012 / Arginine consumption by the intestinal parasite Giardia intestinalis reduces proliferation of intestinal epithelial cells / PLoS One 79:e45325
Fink MY / 2017 / The intersection of immune responses, microbiota, and pathogenesis in giardiasis / Trends Parasitol 33:901~913
Eckmann L / 2003 / Mucosal defense against Giardia / Parasite Immunol 25:259~270
Eckmann L / 2000 / Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia / J Immunol 1643:1478~1487
Stadelmann B / 2012 / Arginine consumption by the intestinal parasite Giardia intestinalis reduces proliferation of intestinal epithelial cells / PLoS One 79:e45325
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UCI(KEPA) : I410-ECN-0101-2020-513-000262953