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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.2
- 발행연도
- 2020.6
- 수록면
- 203 - 211 (9page)
- DOI
- 10.3746/pnf.2020.25.2.203
이용수
초록· 키워드
오류제보하기
Lipoteichoic acid (LTA), a component of Gram-positive bacteria cell walls is involved in infective endocarditis (IE), a life-threatening disease. We evaluated for the first time, whether flavonoid rutin (quercetin-3-rutinoside) can block LTA-induced pro-inflammatory response and reactive oxygen species (ROS) production, and reduction of antioxidant enzymes. We found that rutin suppresses LTA effects on the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, as well as the pro-inflammatory enzyme cyclooxygenase-2, preventing phosphorylation of the mitogen-activated protein kinases (MAPKs), p38, and c-Jun N-terminal kinase, and the increase of ROS production induced by LTA. Taken together, these findings suggest that rutin prevents oxidative damage, inflammation, and MAPKs activation induced by LTA. Rutin may exert a protective effect in IE. These data provide novel insights for future use of rutin to prevent the mechanisms of LTA-related pathogenesis, inflammatory processes, and antioxidant enzyme levels in diseases such as IE.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (41)
참고문헌 신청
Al-Dhabi NA / 2015 / An up-to-date review of rutin and its biological and pharmacological activities / EXCLI J 14:59~63
Ballet M / 1995 / Infective endocarditis due to Streptococcus bovis. A report of 53cases / Eur Heart J. 16:1975~1980
Chen S / 2018 / Myricetin protects cardiomyocytes from LPS-induced injury / Herz 43:265~274
Cunha BA / 2010 / Viridans streptococcal(Streptococcus intermedius)mitral valve subacute bacterial endocarditis(SBE)in a patient with mitral valve prolapse after a dental procedure : the importance of antibiotic prophylaxis / Heart Lung 39:64~72
Dar MA / 2012 / Rutin-potent natural thrombolytic agent / Int Curr Pharm J 1:431~435
Ballet M / 1995 / Infective endocarditis due to Streptococcus bovis. A report of 53cases / Eur Heart J. 16:1975~1980
Chen S / 2018 / Myricetin protects cardiomyocytes from LPS-induced injury / Herz 43:265~274
Cunha BA / 2010 / Viridans streptococcal(Streptococcus intermedius)mitral valve subacute bacterial endocarditis(SBE)in a patient with mitral valve prolapse after a dental procedure : the importance of antibiotic prophylaxis / Heart Lung 39:64~72
Dar MA / 2012 / Rutin-potent natural thrombolytic agent / Int Curr Pharm J 1:431~435
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