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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 579 - 585 (7page)
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초록· 키워드
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Rutin is a well-known flavonoid found in buckwheat. Recent studies have demonstrated that the biological actions of rutin include anti-inflammatory and anti-cancer effects, but the underlying molecular mechanisms of these actions are not yet fully understood.
Neoplastic cell transformation is considered a major event that contributes to carcinogenesis, and the present study aimed to determine whether rutin would exert anti-tumor effects via the inhibition of EGF. The present findings demonstrate that rutin inhibited EGF-induced neoplastic cell transformation in JB6 P+ cells primarily by suppressing activity in the MEK/ERK and MKK4/JNK pathways. On the other hand, rutin had no effect on the phosphorylation of MKK3/6 and p38. Collectively, these results suggest that rutin exerted a potent inhibitory influence on the molecular activity of the MEK/ERK and MKK4/JNK pathways and strongly attenuated EGF-induced neoplastic cell transformation.
These findings provide insight into the biological actions of rutin and the molecular basis for the development of new chemoprotective agents.
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참고문헌 (24)
참고문헌 신청
Alonso-Castro AJ / 2013 / Rutin exerts antitumor effects on nude mice bearing SW480tumor / Arch Med Res 44:346~351
Balkwill F / 2001 / Inflammation and cancer: Back to Virchow? / Lancet 357:539~545
Bode AM / 2003 / Mitogen-activated protein kinase activation in UV-induced signal transduction / Sci STKE 167:RE2
Chang Q / 2009 / Sustained JNK1activation is associated with altered histone H3 methylations in human liver cancer / J Hepatol 50:323~333
Choi KS / 2014 / Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin : p38 MAP kinase and JNK as potential targets / Arch Biochem Biophys 559:38~45
Balkwill F / 2001 / Inflammation and cancer: Back to Virchow? / Lancet 357:539~545
Bode AM / 2003 / Mitogen-activated protein kinase activation in UV-induced signal transduction / Sci STKE 167:RE2
Chang Q / 2009 / Sustained JNK1activation is associated with altered histone H3 methylations in human liver cancer / J Hepatol 50:323~333
Choi KS / 2014 / Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin : p38 MAP kinase and JNK as potential targets / Arch Biochem Biophys 559:38~45
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