지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 235 - 249 (15page)
이용수
초록· 키워드
오류제보하기
Leptin is a type of adipokine mainly produced by adipocytes and reported to be overproduced in prostate cancer. However, it is not known whether it stimulates the proliferation of prostate cells. In this study, we investigated whether benign prostatic hyperplasia epithelial cells (BPH-1 cells) infected with Trichomonas vaginalis induced the proliferation of prostate cells via a leptin signaling pathway. To investigate the effect of crosstalk between adipocyte leptin and inflamed epithelial cell in proliferation of prostate cells, adipocytes 3T3-L1 cells were incubated in conditioned medium of BPH-1 cells infected with T. vaginalis (T. vaginalis-conditioned medium, TCM), and then the adipocyte-conditioned medium (ATCM) was identified to cause proliferation of prostate cells. BPH-1 cells incubated with live T. vaginalis released pro-inflammatory cytokines, and conditioned medium of these cells caused migration of adipocytes. When prostate stromal cells and BPH-1 cells were incubated with adipocyte conditioned medium containing leptin, their growth rates increased as did expression of the leptin receptor (known as OBR) and signaling molecules such as JAK2/STAT3, Notch and survivin. Moreover, blocking the OBR reduced this proliferation and the expression of leptin signaling molecules in response to ATCM. In conclusion, our findings show that inflamed BPH-1 cells infected with T. vaginalis induce the proliferation of prostate cells through leptin-OBR signaling. Therefore, it is likely that T. vaginalis contributes to prostate enlargement in BPH via adipocyte leptin released as a result of inflammation of the prostate.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (59)
참고문헌 신청
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Newman L / 2015 / Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting / PLoS One 10:e0143304
Sutcliffe S / 2012 / Trichomonosis, a common curable STI, and prostate carcinogenesis--a proposed molecular mechanism / PLoS Pathog 8:e1002801
Jong Jin Lee / 2012 / PCR for Diagnosis of Male Trichomonas vaginalis Infection with Chronic Prostatitis and Urethritis / The Korean Journal of Parasitology 50(2):157~159
Mitteregger D / 2012 / High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue / Med Microbiol Immunol 201:113~116
Newman L / 2015 / Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting / PLoS One 10:e0143304
Sutcliffe S / 2012 / Trichomonosis, a common curable STI, and prostate carcinogenesis--a proposed molecular mechanism / PLoS Pathog 8:e1002801
Jong Jin Lee / 2012 / PCR for Diagnosis of Male Trichomonas vaginalis Infection with Chronic Prostatitis and Urethritis / The Korean Journal of Parasitology 50(2):157~159
Mitteregger D / 2012 / High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue / Med Microbiol Immunol 201:113~116
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UCI(KEPA) : I410-ECN-0101-2021-513-001841469