지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 13 (13page)
이용수
초록· 키워드
오류제보하기
Nonallergic eosinophilic asthma (NAEA) is a clinically distinct subtype of asthma. Thus far, the pathophysiologic mechanisms underlying NAEA have not been fully elucidated. This study aimed to determine the role of IL-23 in the pathogenesis of NAEA. We developed a murine model of NAEA using recombinant IL-23 (rIL-23) plus a nonspecific airway irritant [polyinosinic-polycytidylic acid (polyI:C) or diesel exhaust particles (DEPs)] and investigated whether IL23 plays an important role in the development of NAEA. Intranasal administration of rIL-23 (0.1μg/mouse) plus polyI:C (0.01μg/mouse) or DEPs (10μg/mouse) without allergen resulted in methacholine bronchial hyperresponsiveness and eosinophilic airway inflammation in mice, which are characteristic features of NAEA. rIL-23 plus a low dose nonspecific airway irritants induced the release of innate cytokines from airway epithelium, including IL-33, thymic stromal lymphopoietin and IL-1β; these factors activated types 2 and 3 innate lymphoid cells (ILC2s and ILC3s). ILC2s and ILC3s, but not CD4+ T cells (i.e., adaptive immune cells), were important in the development of NAEA. In addition, we observed that IL-23 receptor expressions increased in airway epithelial cells, which suggests the existence of a positive autocrine loop in our murine model of NAEA. To our knowledge, this is the first report in which administration of rIL-23 plus a nonspecific airway irritant (polyI:C or DEPs) without allergen resulted in features of NAEA in mice similar to those found in humans. IL-23 may constitute a therapeutic target for NAEA in humans.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Interleukin-2/antibody complex expanding Foxp3＋ regulatory T cells exacerbates Th2-mediated allergic airway inflammation
BMB Reports
2019 .01
-
Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma
Experimental and Molecular Medicine
2021 .06
-
The role of meningeal populations of type II innate lymphoid cells in modulating neuroinflammation in neurodegenerative diseases
Experimental and Molecular Medicine
2021 .09
-
A novel IL-10-producing innate lymphoid cells (ILC10) in a contact hypersensitivity mouse model
BMB Reports
2016 .01
-
A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy
Experimental and Molecular Medicine
2024 .08
-
IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer
Experimental and Molecular Medicine
2021 .05
-
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
Experimental and Molecular Medicine
2020 .12
-
IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner
Experimental and Molecular Medicine
2024 .03
-
The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
Experimental and Molecular Medicine
2015 .01
-
IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
Experimental and Molecular Medicine
2017 .01
-
S-adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress
Experimental and Molecular Medicine
2016 .01
-
Micrococcus luteus-derived extracellular vesicles attenuate neutrophilic asthma by regulating miRNAs in airway epithelial cells
Experimental and Molecular Medicine
2023 .01
-
Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy
Experimental and Molecular Medicine
2017 .01
-
Oxygen matters: hypoxia as a pathogenic mechanism in rhinosinusitis
BMB Reports
2018 .01
-
Interleukin-32: Frenemy in cancer?
BMB Reports
2019 .01
-
Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease
Experimental and Molecular Medicine
2024 .06
-
Polyinosinic:polycytidylic acid regulates the regenerative migration of BEAS-2B bronchial epithelial cells via primary cilium formation
대한기계학회 춘추학술대회
2022 .04
-
Study on Robot Path Error Compensation System Applied with ILC Using Acceleration Sensor
Journal of the Korean Society for Precision Engineering
2022 .03
-
인간 폐 도관 구조의 유체역학적 고찰
대한기계학회 춘추학술대회
2015 .11
-
hMSCs suppress neutrophil-dominant airway inflammation in a murine model of asthma
Experimental and Molecular Medicine
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0