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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 223 - 228 (6page)
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초록· 키워드
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Dysregulation of histone deacetylase 6 (HDAC6) can lead to the pathologic states and result in the development of various diseases including cancers and inflammatory diseases. The objective of this study was to elucidate the regulatory role of microRNA-22 (miR-22) in HDAC6-mediated expression of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated macrophages. LPS stimulation induced HDAC6 expression, but suppressed miR-22 expression in macrophages, suggesting possible correlation between HDAC6 and miR-22. Luciferase reporter assays revealed that 3’UTR of HDAC6 was a bona fide target site of miR-22. Transfection of miR-22 mimic significantly inhibited LPS-induced HDAC6 expression, while miR-22 inhibitor further increased LPS-induced HDAC6 expression. LPS-induced activation of NF-B and AP-1 was inhibited by miR-22 mimic, but further increased by miR-22 inhibitor. LPS-induced expression of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6 was inhibited by miR-22 mimic, but further increased by miR-22 inhibitor. Taken together, these data provide evidence that miR-22 can downregulate LPS-induced expression of proinflammatory cytokines via suppression of NF-B and AP-1 axis by targeting HDAC6 in macrophages.
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참고문헌 (26)
참고문헌 신청
Vijay K / 2018 / Toll-like receptors in immunity and inflammatory diseases : Past, present, and future / Int Immunopharmacol 59:391~412
Ben-Neriah Y / 2011 / Inflammation meets cancer, with NF-kappaB as the matchmaker / Nat Immunol 12:715~723
Zhang X / 2008 / Macrophage activation by endogenous danger signals / J Pathol 214:161~178
Yan B / 2014 / HDAC6 deacetylase activity is critical for lipopolysaccharide-induced activation of macrophages / PLoS One 9:e110718
Yan B / 2018 / Histone deacetylase 6modulates macrophage infiltration during inflammation / Theranostics 8:2927~2938
Ben-Neriah Y / 2011 / Inflammation meets cancer, with NF-kappaB as the matchmaker / Nat Immunol 12:715~723
Zhang X / 2008 / Macrophage activation by endogenous danger signals / J Pathol 214:161~178
Yan B / 2014 / HDAC6 deacetylase activity is critical for lipopolysaccharide-induced activation of macrophages / PLoS One 9:e110718
Yan B / 2018 / Histone deacetylase 6modulates macrophage infiltration during inflammation / Theranostics 8:2927~2938
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