지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 131 - 138 (8page)
이용수
초록· 키워드
오류제보하기
Cardiac hypertrophy is a form of global remodeling, althoughthe initial step seems to be an adaptation to increased hemodynamicdemands. The characteristics of cardiac hypertrophyinclude the functional reactivation of the arrested fetal geneprogram, where histone deacetylases (HDACs) are closely linkedin the development of the process. To date, mammalianHDACs are divided into four classes: I, II, III, and IV. By structuralsimilarities, class II HDACs are then subdivided into IIaand IIb. Among class I and II HDACs, HDAC2, 4, 5, and 9 havebeen reported to be involved in hypertrophic responses; HDAC4,5, and 9 are negative regulators, whereas HDAC2 is a pro-hypertrophicmediator. The molecular function and regulation ofclass IIa HDACs depend largely on the phosphorylation-mediatedcytosolic redistribution, whereas those of HDAC2 takeplace primarily in the nucleus. In response to stresses, posttranslationalmodification (PTM) processes, dynamic modificationsafter the translation of proteins, are involved in the regulationof the activities of those hypertrophy-related HDACs. Inthis article, we briefly review 1) the activation of HDAC2 inthe development of cardiac hypertrophy and 2) the PTM ofHDAC2 and its implications in the regulation of HDAC2activity.
목차
등록된 정보가 없습니다.
참고문헌 (60)
참고문헌 신청
Johnstone RW / 2002 / Histone-deacetylase inhibitors: novel drugs for the treatment of cancer / Nat Rev Drug Discov 1:287~299
Kee HJ / 2011 / Trichostatin A prevents neointimal hyperplasia via activation of Kruppel like factor 4 / Vascul Pharmacol 55:127~134
Cincarova L / 2013 / New perspectives of valproic acid in clinical practice / Expert Opin Investig Drugs 22:1535~1547
Liu F / 2008 / Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin / J Mol Cell Cardiol 45:715~723
Zhao TC / 2007 / Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury / Cardiovasc Res 76:473~481
Kee HJ / 2011 / Trichostatin A prevents neointimal hyperplasia via activation of Kruppel like factor 4 / Vascul Pharmacol 55:127~134
Cincarova L / 2013 / New perspectives of valproic acid in clinical practice / Expert Opin Investig Drugs 22:1535~1547
Liu F / 2008 / Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin / J Mol Cell Cardiol 45:715~723
Zhao TC / 2007 / Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury / Cardiovasc Res 76:473~481
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A short guide to histone deacetylases including recent progress on class II enzymes
Experimental and Molecular Medicine
2020 .02
-
cAMP signaling increases histone deacetylase 8 expression via the Epac2–Rap1A–Akt pathway in H1299 lung cancer cells
Experimental and Molecular Medicine
2017 .01
-
MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages
BMB Reports
2020 .01
-
Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERKsignaling via PKA and Epac pathways in human lung cancer Cells
Experimental and Molecular Medicine
2016 .01
-
Histone deacetylase 3 promotes alveolar epithelial–mesenchymal transition and fibroblast migration under hypoxic conditions
Experimental and Molecular Medicine
2022 .07
-
Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer
Experimental and Molecular Medicine
2019 .01
-
Modulation of gene expression dynamics by co-transcriptional histone methylations
Experimental and Molecular Medicine
2017 .01
-
Author Correction: PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart
Experimental and Molecular Medicine
2019 .01
-
A novel HDAC6 inhibitor, CKD-504, is effective in treating preclinical models of huntington’s disease
BMB Reports
2023 .03
-
Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway
BMB Reports
2017 .01
-
유전자재조합 CHO 세포에서 Histone Deacetylase Inhibitor를 이용한 Albumin-erythropoietin 생산성 증진
KSBB Journal
2015 .02
-
Proteasome inhibitors attenuated cholesterol-induced cardiac hypertrophy in H9c2 cells
BMB Reports
2016 .01
-
Direct Conversion of Human Fibroblasts to Functional Osteoblasts Using a Histone Deacetylase Inhibiting Small Molecule
한국생물공학회 학술대회
2020 .10
-
The Synergistic Anti-cancer Effect of Histone Deacetylase Inhibitor and Temozolomide in Various Glioblastoma Cell Lines
한국생물공학회 학술대회
2024 .09
-
Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
Experimental and Molecular Medicine
2022 .05
-
Entinostat, a histone deacetylase inhibitor, increases the population of IL-10+ regulatory B cells to suppress contact hypersensitivity
BMB Reports
2021 .10
-
Erratum : Suberoylanilide hydroxamic acid suppresses axonal damage and neurological dysfunction after subarachnoid hemorrhage via the HDAC1/HSP70/TDP-43 axis
Experimental and Molecular Medicine
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0