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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제1호
- 발행연도
- 2020.1
- 수록면
- 17 - 27 (11page)
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초록· 키워드
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Cyclodextrins (CDs) have been used in many pharmaceutical formulations as their constitution and inherent shape present advantages for drugs with poor aqueous solubility and low bioavailability. Because CDs can act as drug carriers by forming inclusion complexes to conjugate with many drugs, they have been applied in many drug delivery systems and can be used to develop new strategies. The objectives of this review are to describe the role of CDs in local administration, the ways in which CDs are used, and relevant studies currently underway. The basic structure and characteristics of CDs, as well as the mechanisms used to formulate inclusion complexes to solubilize drugs are also described. Several studies have been conducted to investigate the use of CDs and most have shown improvements in drug solubility and bioavailability. CDs show potential not only in the pharmaceutical industry but also in a variety of applications, and further research into the use of other drug carriers is therefore necessary.
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참고문헌 (77)
참고문헌 신청
Amidon GL / 1995 / Theoretical basis for a biopharmaceutical drug classification : the correlation of in vitro drug product dissolution and in vivo bioavailability / Pharm Res 12(3):413~420
Aqil F / 2013 / Bioavailability of phytochemicals and its enhancement by drug delivery systems / Cancer Lett 334(1):133~141
Arima H / 1992 / Use of water-soluble beta-cyclodextrin derivatives as carriers of anti-inflammatory drug biphenylylacetic acid in rectal delivery / Yakugaku Zasshi 112(1):65~72
Arima H / 1996 / Possible enhancing mechanism of the cutaneous permeation of 4-biphenylylacetic acid by β-cyclodextrin derivatives in hydrophilic ointment / Chem Pharm Bull 44(3):582~586
Arima H / 1998 / Enhancing effect of hydroxypropyl-β-cyclodextrin on cutaneous penetration activation of ethyl 4-biphenylyl acetate in hairless mouse skin / Eur J Pharm Sci 6(1):53~59
Aqil F / 2013 / Bioavailability of phytochemicals and its enhancement by drug delivery systems / Cancer Lett 334(1):133~141
Arima H / 1992 / Use of water-soluble beta-cyclodextrin derivatives as carriers of anti-inflammatory drug biphenylylacetic acid in rectal delivery / Yakugaku Zasshi 112(1):65~72
Arima H / 1996 / Possible enhancing mechanism of the cutaneous permeation of 4-biphenylylacetic acid by β-cyclodextrin derivatives in hydrophilic ointment / Chem Pharm Bull 44(3):582~586
Arima H / 1998 / Enhancing effect of hydroxypropyl-β-cyclodextrin on cutaneous penetration activation of ethyl 4-biphenylyl acetate in hairless mouse skin / Eur J Pharm Sci 6(1):53~59
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