Prognostic Factors and Clinical Outcome in Parotid Gland Tumors: a Single Institution Experience from the Eastern Black Sea Region of Turkey

Kandaz, Mustafa; Soydemir, Gulsen; Bahat, Zumrut; Canyilmaz, Emine; Yoney, Adnan

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저자정보: Kandaz, Mustafa (Department of Radiation Oncology, Faculty of Medicine, Trabzon, Karadeniz Technical University) Soydemir, Gulsen (Department of Radiation Oncology, Faculty of Medicine, Trabzon, Karadeniz Technical University) Bahat, Zumrut (Department of Radiation Oncology, Faculty of Medicine, Trabzon, Karadeniz Technical University) Canyilmaz, Emine (Department of Radiation Oncology, Faculty of Medicine, Trabzon, Karadeniz Technical University) Yoney, Adnan (Department of Radiation Oncology, Faculty of Medicine, Trabzon, Karadeniz Technical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제3호

발행연도: 2016.1

수록면: 1,169 - 1,174 (6page)

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Purpose: To review clinical characteristics, treatment outcomes and prognostic factors in patients with parotid gland tumors treated with surgery and postoperative radiotherapy. Materials and Methods: We retrospectively reviewed 69 patients with parotid gland tumors, with a median follow-up of 52 months (range, 2-228 months). and a median radiotherapy dose of 60Gy (range, 30-69 Gy). Results: There were 24 (35%) females and 45 (65%) males, at a ratio of 1/1.9. Median age at presentation was $58.9{\pm}17.2$ (range 13-88) years. The most common histology was adenoid cystic carcinoma (33%) and mucoepidermoid carcinoma (28%). The mean overall survival (OS) was $65.3{\pm}8$ (95% confidence interval [CI], 49.6-81.1) months and the median overall survival was $40.0{\pm}7$ (95% CI, 26.2-53.7) months. The -1, -3, -5 and -10 year OS rates were 78%, 52.4%, 35.3% and 19.6% respectively. The mean disease free survival (DFS) was $79.2{\pm}10$ (95% CI, 59.3-97.1) months and the median disease free survival was $38{\pm}13$ (95% CI, 7.05-88.7) months. The -1,-3,-5 and -10 year DFS rates were 71.9%, 50.1%, 43.7% and 30.1% respectively. On univariate analysis, the OS was significantly better with female sex (p<0.005), < 50 age (p<0.021), T stage (p<0.0001), absence of lymph node involvement (p<0.0001), lower tumor grade (p<0.0001), absence of lymphovascular invasion (p<0.002), absence of perineural invasion (p<0.0001), absence of extracapsuler extension (p<0.0001), surgical margin negativity (p<0.006), ${\leq}60Gy$ radiotherapy dose (p<0.0001) and absence of distant metastasis (p<0.027). Conclusions: Employing existing standards of postoperative radiotherapy is a possible treatment that was found to be mainly effective in patients with parotid gland carcinomas.

#Parotid gland cancers #patients characteristics #clinical outcome #prognostic factors

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Kandaz, Mustafa

소속기관 Department of Radiation Oncology, Faculty of Medicine, Trabzon, Karadeniz Technical University