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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,006 - 1,011 (6page)
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초록· 키워드
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Purpose: Lysyl oxidase (LOX) controls the cross-linking and maturation of elastin and collagen fibers. In this study, we investigated the association between LOX gene polymorphisms and intracranial aneurysm (IA) formation in a homogeneous Korean population.
Materials and Methods: This cross-sectional study involved 80 age-sex matched patients with IA and controls. Fisher’s exact test was performed to analyze allelic associations between ten single nucleotide polymorphisms (SNPs) and IA, including 41 rupturedand 39 unruptured cases. Haplotype-specific associations were analyzed using the omnibus test estimating asymptotic chi-square statistics.
Results: Of ten SNPs, three SNPs (rs2303656, rs3900446, and rs763497) were significantly associated with IA (p<0.01). The C allele of rs3900446 was significantly related to increased IA risk with a significant threshold [odds ratio (OR)=20.15, p=4.8×10-5]. Meanwhile,the A allele of rs2303656 showed a preventive effect against IA formation (p=8.2×10-4). Seventeen of 247 haplotype structuresshowed a suggestive association with IA (asymptotic p<0.001). Of ten SNP haplotype combinations, the CG combination of rs3900446 and rs763497 reached Bonferroni-adjusted significant threshold in IA patients (minor haplotype frequency=0.113, asymptoticp=1.3×10-5). However, there was no association between aneurysm rupture and the LOX gene.
Conclusion: This preliminary study indicated that LOX gene polymorphisms, such as rs2303656, rs3900446, and rs763497, may play crucial roles in IA formation in the Korean population. Our novel findings need to be validated in a large-scale independent population.
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참고문헌 (25)
참고문헌 신청
Alg VS / 2013 / Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals / Neurology 80 : 2154 ~ 2165
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 : 263 ~ 265
Cho YD / 2015 / Progressive thrombosis of small saccular aneurysms filled with contrast immediately after coil embolization: analysis of related factors and long-term follow
Hofer A / 2004 / Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families / Cerebrovasc Dis 18 : 189 ~ 193
Hoi Y / 2004 / Effects of arterial geometry on aneurysm growth: threedimensional computational fluid dynamics study / J Neurosurg 101 : 676 ~ 681
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 : 263 ~ 265
Cho YD / 2015 / Progressive thrombosis of small saccular aneurysms filled with contrast immediately after coil embolization: analysis of related factors and long-term follow
Hofer A / 2004 / Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families / Cerebrovasc Dis 18 : 189 ~ 193
Hoi Y / 2004 / Effects of arterial geometry on aneurysm growth: threedimensional computational fluid dynamics study / J Neurosurg 101 : 676 ~ 681
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