지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : Since some studies have shown that the brain-derived neurotrophic factor(BDNF) has an important role in the pathophysiology of depression, this study investigated the relationship between BDNF genetic polymorphism and the long-term outcome of the antidepressant treatment. Method : One hundred and eight patients with major depressive disorder were evaluated for the long-term outcome(up to 3 years) of antidepressant treatment. The severity and improvement of depression were assessed with the Clinical Global Impression(CGI) Scale. The genotypes of BDNF 196A/G polymorphism in the patients were determined using Restriction Fragment Length Polymorphism(RFLP). Result : The genotypes of 128 patients were investigated and 95 patients of those have been evaluated for 3 years. No significant differences were noted comparing three-genotype groups for CGI scales at baseline, 4 weeks, 8 weeks, 1 year, 2 years and 3 years. Conclusion : This result shows that BDNF polymorphism investigated in this study was not associated with the long-term outcome of the antidepressant treatment. However, further studies with another BDNF polymorphism should be needed.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
우울증에서 Brain - Derived Neurotrophic Factor의 역할
생물치료정신의학
2005 .12
-
Effects of BDNF Polymorphisms on Antidepressant Action
PSYCHIATRY INVESTIGATION
2010 .01
-
우울증 환자의 혈액에서 측정되는 BDNF 농도 변화와 그 의미
신경정신의학
2009 .01
-
The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment
PSYCHIATRY INVESTIGATION
2010 .01
-
Brain-derived Neurotrophic Factor Is Associated with Cognitive Impairment in Elderly Korean Individuals
Clinical Psychopharmacology and Neuroscience
2015 .01
-
Brain-Derived Neurotrophic Factor Val66Met 다형성과 정신분열병의 관련 연구
생물정신의학
2006 .01
-
A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia
Clinical Psychopharmacology and Neuroscience
2012 .01
-
Brain-Derived Neurotrophic Factor와 알쯔하이머병
생물치료정신의학
2005 .12
-
정신분열병 환자의 혈청에서 Brain-Derived Neurotrophic Factor 증가
생물정신의학
2004 .01
-
Effect of the Presence of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on the Recovery in Patients With Acute Subcortical Stroke
Annals of Rehabilitation Medicine
2013 .01
-
Gender-Specific Association of the Brain-Derived Neurotrophic Factor Gene with Attention-Deficit/Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2010 .01
-
Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
PSYCHIATRY INVESTIGATION
2014 .01
-
Association of the Brain-derived Neurotrophic Factor Gene and Clinical Features of Bipolar Disorder in Korea
Clinical Psychopharmacology and Neuroscience
2012 .01
-
A Longitudinal Study of BDNF Promoter Methylation and Depression in Breast Cancer
PSYCHIATRY INVESTIGATION
2015 .01
-
Decreased Plasma BDNF Levels of Patients with Somatization Disorder
PSYCHIATRY INVESTIGATION
2016 .01
-
Brain-Derived Neurotrophic Factor(BNDF) Val66Met 유전자 다형성과 성격 특성에 대한 연합연구
생물정신의학
2005 .01
-
The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder
PSYCHIATRY INVESTIGATION
2010 .01
-
Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder
PSYCHIATRY INVESTIGATION
2014 .01
-
지연성 운동장애와 BDNF(Brain-derived Neurotrophic Factor) Val66Met 유전자 다형성과의 연관성연구
생물치료정신의학
2006 .06
-
Association between the BDNF Val66Met Polymorphism and Chronicity of Depression
PSYCHIATRY INVESTIGATION
2013 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0