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초록· 키워드
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Green tea catechins (GTC) and its major component, (-)-epigallocatechin gallate (EGCG) were studied for their protective effects against reactive oxygen species (ROS)-induced oxidative stress. GTC and EGCG skewed the strong antioxidative effects on the lipid peroxidation of ethyl linolate with Fenton's reagent and free radical scavenging effect to DPPH radical generation. They also protected $H_2O$$_2$- or KO$_2$-induced cytotoxicity in CHL cells or mouse splenocytes. These results indicate that GTC and EGCG are capable of protecting the lipid peroxidation, flee radical generation and cytotoxicity induced by ROS. The mechanism of inhibition in ROS-induced cytotoxicity may be due to their antiofidative and free radical scavenging properties. Therefore, GTC and EGCG may be useful chemopreventive agents by protecting the free radical generation which are involved in cancer and aging.
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Protective Effect of EGCG Against Reactive Oxygen Species-induced Stress
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Epigallocatechin Gallate, a Constituent of Green Tea, Regulates High Glucose-induced Apoptosis
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Anti-platelet Mechanism of Epigallocatechin Gallate
대한약학회 학술대회
2003 .01
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Epigallocatechine gallate에 의한 amyloid β peptide 유도성 신경세포독성의 억제
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Growth inhibition and induction of apoptosis in cervical cancer cell linesby green tea polyphenols
Obstetrics & Gynecology Science
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Activity of Green Tea Polyphenol Epigallocatechin-3-gallate Against Ovarian Carcinoma Cell Lines
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Effect of Green Tea Catechins on the Expression and Activity of MMPs and Type I Procollagen Synthesis in Human Dermal Fibroblasts
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녹차에 의한 직업성 천식 및 비염 1예
천식 및 알레르기
2009 .01
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(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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The Protective Effect of Epigallocatechin-3 Gallate on Ischemia/ Reperfusion Injury in Isolated Rat Hearts: An ex vivo Approach
The Korean Journal of Physiology & Pharmacology
2011 .01
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Epigallocatechin-3-gallate Inhibits LPS-Induced NF-κB and MAPK Signaling Pathways in Bone Marrow-Derived Macrophages
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난소암 세포주에서 녹차 추출물의 항암 작용
Obstetrics & Gynecology Science
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Pharmacokinetic and Pharmacodynamic Interaction between Metformin and (-)-Epigallocatechin-3-gallate
Molecular & cellular toxicology
2009 .01
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체중감량 목적으로 사용되는 녹차추출물의 임상정보
한국임상약학회지
2018 .01
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녹차 분말과 카테킨의 농도에 따른 항산화력 비교 분석
동의생리병리학회지
2005 .01
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Epigallocatechin-3-gallate, a green tea catechin, protects the heart against regional ischemia-reperfusion injuries through activation of RISK survival pathways in rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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