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Influence of berberine on the blood pressure of rabbits
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Type
Academic journal
Author
Ko, Suk-Tai (College of Pharmacy and College of Medicine, Chosun University) Lim, Dong-Yoon (College of Pharmacy and College of Medicine, Chosun University)
Journal
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제3권 제1호 SCOPUS
Published
1980.1
Pages
23 - 30 (8page)

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Influence of berberine on the blood pressure of rabbits
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Berberine, when administered into a ear-vein of the rabbit anesthetized with urethane, produced a long-lasting, dose related fall in blood pressure, but intraventricular berberline did not elicit the hypotensive response. This hypotensive activity of berberine was not influenced by pretreatment of vagotomization and atropine. Depressor responses induced by berberine were not impaired by diphenhydramine, chlorisondamine, guanethidine and propranolol, but reduced significantly by phentolamine pretreatment. Berberine attenuated markedly prossor responses of norepinephrine and epinephrine. These results suggest that berberine causes the hypotensive activity that is attributable to alpha adrenoceptor blockade, but not to a direct relaxant effect upon vascular smooth muscle.
#Berberine-depressor activity- alpha adrenoceptor blockade

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