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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 116 - 123 (8page)
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Objectives : The present study was designed to investigate effects and molecular mechanisms of Atractylodes macrocephala Koidzumi extracts(AMK) on the improvement of adipocyte dysfunction induced by TNF-${\alpha}$ in 3T3-L1 adipocytes. We examined whether AMK could directly influence the inflammation and insulin resistance in 3T3-L1 adipocytes. Methods : Potential roles of AMK in the lipolysis, production of inflammatory adipokines and ROS, expression and phosphorylation of ERK, JNK, and $I{\kappa}B{\alpha}$ protein, and expression of $PPAR{\gamma}$ and C/EBP${\alpha}$ were investigated in this study. Results : Our data demonstrated that TNF-${\alpha}$ significantly increased lipolysis, levels of MCP-1, IL-6, and ROS and phosphorylation of ERK, JNK, and $I{\kappa}B{\alpha}$ protein, while TNF-${\alpha}$ reduced the expression of $PPAR{\gamma}$ and C/EBP${\alpha}$ in adipocytes, suggesting that TNF-${\alpha}$ induced a condition with the occurrence of inflammation and insulin resistance. Those alterations induced by TNF-${\alpha}$ were prevented by the treatment of AMK. AMK down-regulated the phosphorylation of ERK, JNK, and $I{\kappa}B{\alpha}$ protein and up-regulated the expression of $PPAR{\gamma}$ and C/EBP${\alpha}$ on TNF-${\alpha}$-induced inflammation and insulin resistance. Conclusions : Thus, our results indicate that AMK can be used to prevent from the TNF-${\alpha}$-induced adipocyte dysfunction through MAPK, $NF{\kappa}B$ and $PPAR{\gamma}$ pathways.
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참고문헌 (40)
참고문헌 신청
Galic S / 2010 / Adipose tissue as an endocrine organ / Molecular and cellular endocrinology 316(2):129~139
Vazquez-Vela ME / 2008 / White adipose tissue as endocrine organ and its role in obesity / Arch Med Res 39(8):715~728
Coppack SW / 2001 / Pro-inflammatory cytokines and adipose tissue / Proc Nutr Soc 60(3):349~356
Chen X / 2009 / TNF-alpha, a potent lipid metabolism regulator / Cell Biochem Funct 27(7):407~416
Chen XH / 2010 / TNF-alpha induces mitochondrial dysfunction in 3T3-L1 adipocytes / Molecular and cellular endocrinology 328(1-2):63~69
Vazquez-Vela ME / 2008 / White adipose tissue as endocrine organ and its role in obesity / Arch Med Res 39(8):715~728
Coppack SW / 2001 / Pro-inflammatory cytokines and adipose tissue / Proc Nutr Soc 60(3):349~356
Chen X / 2009 / TNF-alpha, a potent lipid metabolism regulator / Cell Biochem Funct 27(7):407~416
Chen XH / 2010 / TNF-alpha induces mitochondrial dysfunction in 3T3-L1 adipocytes / Molecular and cellular endocrinology 328(1-2):63~69
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