지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 162 - 170 (9page)
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초록· 키워드
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Objectives : Increasing evidence suggests that parasympathetic vagus nerve activity plays a role in modulating acupuncture-induced anti-inflammatory reaction, but the function of sympathetic nerve is not known. Here, we investigated whether splanchnic sympathetic nerve activity was involved in the regulation of splenic expression of $TNF-{\alpha}$ mRNA by electroacupuncture (EA) in LPS-injected animals. Methods : DiI was injected into the stomach or celiac ganglion (CG) for retrograde labeling of the target tissues. EA was given at ST36 and the electrical stimulation on the sciatic nerve in LPS-injected mice. c-Fos signals in the tissues were analyzed by immunofluorescence staining, and $TNF-{\alpha}$ mRNA was analyzed by real-time PCR. Results : Application of EA at ST36 or electrical stimulation on the sciatic nerve induced c-Fos expression in neurons of the spinal cord and celiac ganglion (CG). Then, the vagotomy reduced c-Fos levels in CG neurons but not in the spinal cord in animals given EA. Expression of $TNF-{\alpha}$ mRNA which was induced in the spleen after LPS was significantly inhibited by EA, then the vagotomy elevated $TNF-{\alpha}$ mRNA level similar to that in LPS-injected animals. Splanchnectomy in animals given LPS and EA also increased $TNF-{\alpha}$ mRNA though it was less effective than vagotomy. Conclusions : Our data suggest that EA delivered to the spleen via the splanchnic sympathetic nerve may be involved in attenuating splenic inflammatory responses in LPS-injected animals.
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참고문헌 (23)
참고문헌 신청
Leake R / 1999 / Treatment of efficacy of acupuncture: a review of the research literature / Integrative Med 1:107~115
Ji-Yeun Park / 2018 / Electroacupuncture therapy in inflammation regulation: current perspectives / Journal of Inflammation Research Volume 11:227~237
Tracey KJ / 2002 / The inflammatory reflex / Nature 420(6917):853~859
Hee-Don Lim / 2016 / Anti-Inflammatory Effects of Acupuncture Stimulation via the Vagus Nerve / PLOS ONE 11(3):e0151882
Haifeng Jin / 2017 / Anti-inflammatory effects and mechanisms of vagal nerve stimulation combined with electroacupuncture in a rodent model of TNBS-induced colitis / American Journal of Physiology-Gastrointestinal and Liver Physiology 313(3):G192~G202
Ji-Yeun Park / 2018 / Electroacupuncture therapy in inflammation regulation: current perspectives / Journal of Inflammation Research Volume 11:227~237
Tracey KJ / 2002 / The inflammatory reflex / Nature 420(6917):853~859
Hee-Don Lim / 2016 / Anti-Inflammatory Effects of Acupuncture Stimulation via the Vagus Nerve / PLOS ONE 11(3):e0151882
Haifeng Jin / 2017 / Anti-inflammatory effects and mechanisms of vagal nerve stimulation combined with electroacupuncture in a rodent model of TNBS-induced colitis / American Journal of Physiology-Gastrointestinal and Liver Physiology 313(3):G192~G202
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