지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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We investigated the role of L-type $Ca^{2+}$ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type $Ca^{2+}$ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type $Ca^{2+}$ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.
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참고문헌 (15)
참고문헌 신청
Takahashi, N / 1988 / Osteoblastic cells are involved in osteoclast formation / Endocrinology 123:2600
Suda, T / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr. Rev 20:345
Wong, B. R / 1997 / TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun Nterminal kinase in T cells / J. Biol. Chem 272:25190
Yasuda, H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL / Proc.Natl. Acad. Sci. USA 95:3597
Lacey, D. L / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165
Suda, T / 1999 / Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families / Endocr. Rev 20:345
Wong, B. R / 1997 / TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun Nterminal kinase in T cells / J. Biol. Chem 272:25190
Yasuda, H / 1998 / Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL / Proc.Natl. Acad. Sci. USA 95:3597
Lacey, D. L / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93:165
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