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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Rosae Multiflorae fructus (RMF), known to have anti-inflammatory and antioxidant properties, has been used as a traditional remedy for inflammatory diseases such as arthritis in Eastern Asia. However, its effect on osteoclasts, which play a crucial role in resorptive inflammatory bone diseases, is yet to be elucidated. Methods: The effect of extract of RMF (RMF-E) on receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis was examined by tartrate-resistant acid phosphatase (TRAP) staining, real-time polymerase chain reaction and western blot analysis. In addition, RANKL-induced Ca2+-oscillation was also investigated. Results: RMF-E remarkably inhibited TRAP+-osteoclast and resorptive pit formation in a dose-dependent manner. In addition, the expression of c-Fos and nuclear factor of activated T-cells cytoplasmic, known as pivotal transcription factors for osteoclast formation in vitro and in vivo, and that of the osteoclast differentiation markers such as Acp5, Oscar, CtsK, Atp6v0d2, Tm7sf4, and Nfatc1 were significantly decreased by RMF-E treatment during osteoclastogenesis. The inhibitory effect of RMF-E on RANKL-induced osteoclastogenesis was caused by the suppression of p38 mitogen-activated protein kinase activation, and RANKL-induced Ca2+-oscillation removal via inactivation of Bruton's tyrosine kinase (BTK), and subsequently phospholipase C-γ2. Conclusions: RMF-E negatively regulates osteoclast differentiation and formation. These findings suggest the possibility of RMF-E as a traditional therapeutic agent against osteoclast-related bone disorders such as osteoporosis, rheumatoid arthritis, and periodontitis.
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참고문헌 (33)
참고문헌 신청
Boyle WJ / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Walsh MC / 2006 / Osteoimmunology : interplay between the immune system and bone metabolism / Annu Rev Immunol 24:33~63
Walsh MC / 2014 / Biology of the RANKL-RANK-OPG system in immunity, bone, and beyond / Front Immunol 5:511
Takayanagi H / 2007 / Osteoimmunology : shared mechanisms and crosstalk between the immune and bone systems / Nat Rev Immunol 7:292~304
Shinohara M / 2008 / Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals / Cell 132:794~806
Walsh MC / 2006 / Osteoimmunology : interplay between the immune system and bone metabolism / Annu Rev Immunol 24:33~63
Walsh MC / 2014 / Biology of the RANKL-RANK-OPG system in immunity, bone, and beyond / Front Immunol 5:511
Takayanagi H / 2007 / Osteoimmunology : shared mechanisms and crosstalk between the immune and bone systems / Nat Rev Immunol 7:292~304
Shinohara M / 2008 / Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals / Cell 132:794~806
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