지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 1 - 5 (5page)
이용수
초록· 키워드
오류제보하기
Receptor activator of nuclear factor κB ligand (RANKL)
induces osteoclast formation from hematopoietic cells via
up-regulation of positive regulators, including NF-κB, c-
Fos, microphthalmia transcription factor (Mitf), PU.1, and
nuclear factor of activated T cells (NFAT) c1. In addition to
the positive regulation by these transcription factors,
RANKL appears to regulate negative regulators such as
MafB and inhibitors of differentiation (Ids). Ids and MafB
are abundantly expressed in osteoclast precursors, bone
marrowderived monocyte/macrophage lineage cells (BMMs).
Expression levels of these genes are significantly reduced by
RANKL during osteoclastogenesis. Overexpression of these
genes in BMMs inhibits the formation of tartarate-resistant
acid phosphatase (TRAP)-positive multinuclear osteoclasts
by down-regulation of NFATc1 and osteoclast-associated
receptor (OSCAR), which are important for osteoclast
differentiation. Furthermore, reduced expression of these
genes enhances osteoclastogenesis and increases expression
of NFATc1 and OSCAR. Taken together, RANKL induces
osteoclastogenesis via up-regulation of positive regulators as
well as down-regulation of negative regulators.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
4 Junwon Lee / 1997 / The Maf transcription factors: regulators of differentiation 22 : 437 ~ 41
ANDERSON, D. M / 1997 / A homologue of the TNF receptor and itsligand enhance T-cel growth and dendritic-cell function 390 : 175 ~ 9
ASAGIRI, M / 2005 / Autoamplification of NFATc1 expression determines its essential role in bone homeostasis 202 : 1261 ~ 9
BENEZRA / 1990 / a negativeregulator of helix-lop-helix DNA binding proteins : 49 ~ 59
BOYLE, W. J / 2003 / Osteoclast diferentiation and activation 423 : 37 ~ 42
ANDERSON, D. M / 1997 / A homologue of the TNF receptor and itsligand enhance T-cel growth and dendritic-cell function 390 : 175 ~ 9
ASAGIRI, M / 2005 / Autoamplification of NFATc1 expression determines its essential role in bone homeostasis 202 : 1261 ~ 9
BENEZRA / 1990 / a negativeregulator of helix-lop-helix DNA binding proteins : 49 ~ 59
BOYLE, W. J / 2003 / Osteoclast diferentiation and activation 423 : 37 ~ 42
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulation of NFATc1 in Osteoclast Differentiation
대한골대사학회지
2014 .01
-
Gene Profiling in Osteoclast Precursors by RANKL Using Microarray
대한의생명과학회지
2013 .06
-
P2Y<sub>6</sub> 수용체 길항제의 파골세포 분화 촉진 효과 규명
약학회지
2015 .01
-
cAMP-response Element-binding Protein Is not Essential for Osteoclastogenesis Induced by Receptor Activator of NF-κB Ligand
International Journal of Oral Biology
2005 .01
-
RANK Signaling Pathways and Key Molecules Inducing Osteoclast Differentiation
대한의생명과학회지
2017 .12
-
녹제초 추출물이 파골세포 분화 및 골 흡수에 미치는 영향
한방재활의학과학회지
2019 .01
-
Inhibitory effect of Chaenomelis Fructus ethanol extract on receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis
International Journal of Oral Biology
2020 .01
-
Effect of Cornus Officinalis on Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL)-induced Osteoclast Differentiation
대한골대사학회지
2012 .01
-
Osteoclast Activity and Osteoporosis
한국응용약물학회 춘계학술발표논문집
2001 .01
-
Attenuation of RANKL-induced Osteoclast Formation via p38-mediated NFATc1 Signaling Pathways by Extract of Euphorbia Lathyris L
대한골대사학회지
2016 .01
-
Methanol Extract of Croton Pycnanthus Benth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-κB Signaling Pathways
대한골대사학회지
2014 .01
-
L-형 칼슘 이온통로에 의한 파골세포 분화의 조절
약학회지
2010 .01
-
The Molecular Mechanism of Baicalin on RANKL-induced Osteoclastogenesis in RAW264.7 Cells
International Journal of Oral Biology
2013 .01
-
파골세포 분화에서 토사자 물 추출물의 효과
동의생리병리학회지
2009 .01
-
파골세포의 분화에 커규민의 억제 작용기전
동의생리병리학회지
2008 .01
-
파골세포 분화에 미치는 복분자 물 추출물의 효과
동의생리병리학회지
2011 .01
-
파골세포 분화에 미치는 복분자 물 추출물의 효과
동의생리병리학회지
2011 .08
-
Piperlongumine suppressed osteoclastogenesis in RAW264.7 macrophages
International Journal of Oral Biology
2019 .01
-
Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca2+-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression
대한골대사학회지
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0