지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
BAY11-7082 was initially found to be an anti-inflammatory drug with NF-${\kappa}B$ inhibitory property. In this study, we evaluated modulatory function of BAY11-7082 on U937 cell-cell adhesion induced by CD29 (${\beta}1$-integrins). BAY11-7082 strongly blocked functional activation of CD29 (${\beta}1$-integrins), as assessed by cell-cell adhesion assay. However, this compound did not block a simple activation of CD29, as assessed by cell-fibronectin adhesion assay. In particular, to understand molecular mechanism of BAY11-7082-mediated inhibition, the regulatory roles of CD29-induced actin cytoskeleton rearrangement under cell-cell adhesion and surface level of CD29 were examined using confocal and flow cytometic analysis. Interestingly, this compound strongly suppressed the molecular association of actin cytoskeleton with CD29 at cell-cell adhesion site. Moreover, BAY11-7082 also diminished surface levels of CD29 as well as its-associated adhesion molecule CD147, but not other adhesion molecules such as CD18 and CD43. Therefore, our data suggest that BAY11-7082 may be involved in regulating immune responses managed by CD29-mediated cell-cell adhesion.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
단핵구 기능 수행에서의 $CD29({\beta}1-integrins)$ 조절 역할
약학회지
2008 .01
-
CD29 및 CD98 활성 매개에 의한 Jurkat T 세포의 유착과 그 활용
약학회지
2009 .01
-
CD30-Mediated Regulation of Cell Adhesion Molecule Expression on Murine T Cells
Immune Network
2003 .03
-
Adhesion of CD40-stimulated Germinal Center B Cells to HK Cells Employs the CD11a/CD18-CD54 Interactions
Immune Network
2003 .09
-
Role for CD40 and CD40L Expression in Generating CD8 T Cell Response to Minor Histcompatibility Antigen, H60
Immune Network
2007 .12
-
CD40L 발현 K562 세포주를 이용한 시험관내 B 세포 증식과 항원제공능 증가
Immune Network
2007 .06
-
Effect of Tea Polyphenols on the Adhesion of Highly Metastatic Human Lung Carcinoma Cell Lines to Endothelial Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Regulation of Inflammation by Bidirectional Signaling through CD137 and Its Ligand
Immune Network
2012 .10
-
Cross-linking of CD80 and CD86 Diminishes Expression of CD54 on EBV-transformed B Cells through Inactivation of RhoA and Ras
Immune Network
2011 .12
-
Expression and Function of TLR2 on CD4 Versus CD8 T Cells
Immune Network
2009 .08
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
-
CD137-CD137 Ligand Interactions in Inflammation
Immune Network
2009 .06
-
CD43 Expression Regulated by IL-12 Signaling Is Associated with Survival of CD8 T Cells
Immune Network
2010 .10
-
활성화된 단핵구 및 대식세포의 항원제시기능에 대한 Kaempferitrin의 조절 효과
약학회지
2007 .01
-
결장암에 대한 활성 자연살해세포의 항암효능
약학회지
2010 .01
-
Ginsenoside Rb1의 세포간 유착, 세포표면 단백질 발현 및 세포형태변화에 미치는 효과
Journal of Ginseng Research
2009 .12
-
Requirement of CD4 Help for Induction of CD8 T Cell Response Specific for Virally Derived H60
Immune Network
2012 .06
-
CD44s and CD44v6 Are Predominantly Expressed in the Non-germinal Center B-Cell-like Type of Diffuse Large B-Cell Lymphomas
Journal of Pathology and Translational Medicine
2011 .01
-
마행감석탕가감방(麻杏甘石湯加減方)이 천식모델 생쥐의 CD3, CD4, CD8 세포에 미치는 영향
논문집 : 대전대학교 한의학연구소. 한의학편
2008 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0