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자료유형
학술저널
저자정보
Lee, Jae-Hoon (College of Pharmacy, Sungkyunkwan University) Ha, Won-Shik (College of Pharmacy, Sungkyunkwan University) Chu, Won-Shik (School of Mechanical and Aerospace Engineering, Seoul National University) Park, Chun-Woong (College of Pharmacy, Sungkyunkwan University) Ahn, Sung-Hoon (School of Mechanical and Aerospace Engineering and Institute of Advanced Machinery and Design, Seoul National University) Chi, Sang-Cheol (College of Pharmacy, Sungkyunkwan University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제1호
발행연도
2008.1
수록면
125 - 132 (8page)

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PLGA scaffolds were prepared using a nano-composite deposition system (NCDS). 5-Fluorouracil (5-FU) was used as a model drug. Hydroxyapatite (HA) was included in the scaffolds to improve the mechanical properties of the scaffolds and modulate the release of 5-FU from the scaffolds. 5-FU and HA were dispersed well in the prepared scaffolds when evaluated with SEM, FT-IR, XRPD and DSC. The release of 5-FU from the prepared scaffolds consisting of different compositions was determined using 40 mL PBS as the medium. The release profiles of 5-FU from PLGA scaffolds followed the typical triphasic release pattern. The addition of HA to the compositions increased the release rate of 5-FU from the scaffolds and improved the mechanical properties of the scaffolds, while it retarded the degradation of PLGA. Therefore, NCDS could be a good system to prepare polymeric implants of various shapes with different drug release patterns.

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