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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 348 - 350 (3page)
- DOI
- 10.14348/molcells.2023.0061
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초록· 키워드
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Our sense of smell depends on olfactory sensory neurons (OSNs), each equipped with a single type of olfactory receptor (OR), which determines the projection of the OSN axon to the OR-specific location in the olfactory bulb. The precise regulation of OSN axon targeting is crucial for proper smell perception. A recent study by Shayya et al. (2022) has uncovered a surprising connection between endoplasmic reticulum (ER) stress and precise axon targeting during the formation of the OSN circuits. Specifically, the amino acid sequence of the OR regulates the ER stress levels, which, in turn, modulate the expression of axon guidance molecules through the master regulator transcription factor Ddit3. UPR, unfolded protein response.
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