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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 954 - 965 (12page)
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Mammalian genomes are well established, and highly conserved regions within odorant receptors that are unique from other G-protein coupled receptors have been identified. Nu-merous functional studies have focused on specific conserved amino acids motifs; however, not all conserved motifs have been sufficiently characterized. Here, we identified a highly conserved 18 amino acid sequence motif within transmembrane domain seven (CAS-TM7) which was identified by aligning odorant receptor sequences. Next, we investigated the expression pattern and distribution of this conserved amino acid motif among a broad range of odorant receptors. To examine the localization of odorant receptor proteins, we used a sequence-specific peptide antibody against CAS-TM7 which is specific to odorant receptors across species. The specificity of this peptide antibody in recognizing odorant receptors has been confirmed in a heterologous in vitro system and a rat-based in vivo system. The CAS-TM7 odorant receptors localized with distinct patterns at each region of the olfactory epithelium; septum, endoturbinate and ectoturbinate. To our great interests, we found that the CAS-TM7 odorant receptors are primarily localized to the dorsal region of the olfactory bulb, coinciding with olfactory epithelium-based patterns. Also, these odorant receptors were ectopically expressed in the various non-olfactory tissues in an evolutionary constrained manner between human and rats. This study has characterized the expression patterns of odorant receptors containing particular amino acid motif in transmembrane domain 7, and which led to an intriguing possibility that the conserved motif of odorant receptors can play critical roles in other physiological functions as well as olfaction.
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참고문헌 (55)
참고문헌 신청
Altschul, S. F. / 1997 / Gapped BLAST and PSI-BLAST : a new generation of protein database search programs / Nucleic Acids Res 25:3389~3402
Asai, H. / 1996 / Genomic structure and transcription of a murine odorant receptor gene: differential initiation of transcription in the olfactory and testicular cells / Biochem. Biophys. Res. Commun 221:240~247
Barnea, G. / 2004 / Odorant receptors on axon termini in the brain / Science 304:1468
Braun, T. / 2007 / Enterochromaffin cells of the human gut : sensors for spices and odorants / Gastroenterology 132:1890~1901
Buck, L. / 1991 / A novel multigene family may encode odorant receptors : a molecular basis for odor recognition / Cell 65:175~187
Asai, H. / 1996 / Genomic structure and transcription of a murine odorant receptor gene: differential initiation of transcription in the olfactory and testicular cells / Biochem. Biophys. Res. Commun 221:240~247
Barnea, G. / 2004 / Odorant receptors on axon termini in the brain / Science 304:1468
Braun, T. / 2007 / Enterochromaffin cells of the human gut : sensors for spices and odorants / Gastroenterology 132:1890~1901
Buck, L. / 1991 / A novel multigene family may encode odorant receptors : a molecular basis for odor recognition / Cell 65:175~187
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