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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제59권 제1호
- 발행연도
- 2016.1
- 수록면
- 49 - 56 (8page)
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The current study investigated the anti-obesity effect of Cissus quadrangularsis extracts (CQR-300) and its molecular action mechanism on obese mice induced high-fat diet (HFD). To induce the obesity, mice were fed a HFD for 6 weeks and then fed HFD only or HFD with CQR-300 at 50 and 200 mg/kg. Then, body weight gain and white adipose tissue weights were measured. We investigated the reduction in body fat and the regulation of fatty acid synthesis was measured by dual energy X-ray absorptiometry and real-time PCR with Western blot, respectively. In vitro study, CQR-300 inhibited pancreatic lipase activity. The CQR-300 treatment was significantly decreased the body weight gain and adipocytes size as well as white adipose tissues weights in HFD-induced obese mice. Furthermore, CQR-300 reduced the body fat and fat mass with regulating of adipose tissue hormones as leptin. Treatment with 50 mg/kg CQR-300 showed effectively lower expression levels of adipogenesis/lipogenesis related genes and proteins such as CCAAT/enhancer binding protein ${\alpha}$ ($C/EBP{\alpha}$), peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), Sterol regulatory element binding protein-1c (SREBP-1c), and fatty acid synthase (FAS) in white adipose tissue (WAT) as compared with the HFD fed only mice. These results suggest that the CQR-300 has an anti-obesity effect via inhibition of lipase activity, decrease the body fat mass by regulating the adipogenesis and lipogenesis related genes and proteins in epididymal adipose tissue with evaluate body fat reduce in the HFD-induced obese mice.
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참고문헌 (34)
참고문헌 신청
Anoop A / 2002 / Gastric and duodenal antiulcer and cytoprotective effect of Cissus quadrangularis Linn. Variant II in rats / Nigerian J Nat Prod Med 6:1~7
Birari RB / 2007 / Pancreatic lipase inhibitors from natural sources: unexplored potential / Drug Discovery Today 12:879~889
Campos P / 2005 / The epidemiology of overweight and obesity: public health crisis or moral panic? / Int J Epidemiol 35:55~60
Chen W / 2012 / Abdominal fat analyzed by DEXA scan reflects visceral body fat and improves the phonotype description and the assessment of metabolic risk in mice / Am J Physiol Endocrinol Metab 303:E635~E643
G.A. Ravishankar / 2003 / Antioxidant and Antimicrobial Activity of Cissus quadrangularis L. / Journal of Medicinal Food 6(2):99~105
Birari RB / 2007 / Pancreatic lipase inhibitors from natural sources: unexplored potential / Drug Discovery Today 12:879~889
Campos P / 2005 / The epidemiology of overweight and obesity: public health crisis or moral panic? / Int J Epidemiol 35:55~60
Chen W / 2012 / Abdominal fat analyzed by DEXA scan reflects visceral body fat and improves the phonotype description and the assessment of metabolic risk in mice / Am J Physiol Endocrinol Metab 303:E635~E643
G.A. Ravishankar / 2003 / Antioxidant and Antimicrobial Activity of Cissus quadrangularis L. / Journal of Medicinal Food 6(2):99~105
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