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자료유형
학술저널
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Lim, Jung-Su (Department of Life and Nanopharmaceutical Science, Kyunghee University) Kim, Hyo-Sup (Department of Biology, Kyunghee University) Choi, Yoon-Seok (Department of Biology, Kyunghee University) Kwon, Hyock-Man (Department of Bioscience and Biotechnology & Protein Research Center for Bio-Industry, Hankuk University of Foreign Studies) Shin, Ki-Soon (Department of Life and Nanopharmaceutical Science, Kyunghee University) Joung, In-Sil (Department of Biological Sciences, Hanseo University) Shin, Mi-Jung (REGEN Biotech Inc.) Kim, Yun-Hee (Department of Life and Nanopharmaceutical Science, Kyunghee University)
저널정보
한국통합생물학회 Animal cells and systems Animal cells and systems 제12권 제4호
발행연도
2008.1
수록면
203 - 209 (7page)

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Berberine, an isoquinoline alkaloid found in Coptidis Rhizoma(goldenthread) extract, has multiple pharmacological effects such as anti-inflammatory, antimicrobial and anti-ischemic effects. In the present study, we examined the effects of berberine on neuronal survival and differentiation in a hippocampal precursor cell line and in the memory deficient rat model. Berberine increased in a dose dependent manner the survival of hippocampal precursor cells as well as differentiated cells. In addition, berberine promoted neuronal differentiation of hippocampal precursor cells. In the memory deficient rat model induced by stereotaxic injection of ibotenic acid into entorhinal cortex(Ibo model), hippocampal cells were increased about 2.7 fold in the pyramidal layer of CA1 region and about 2 fold in the dentate gyrus by administration of berberine after 2 weeks of ibotenic acid injection. Furthermore, neuronal cells immunoreactive to calbindin were increased in the hippocampus and entorhinal cortex area by administration of berberine. Taken together, these results suggest that berberine has neuroprotective effect in the Ibo model rat brain by promoting the neuronal survival and differentiation.

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