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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Min-Cheol (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude) Kim, Su-Jin (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude) Choi, In-Young (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude) Ki, Ji-Ye (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude) Kim, Dae-Seung (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude) Jeon, Yong-Deok (Department of Oriental Pharmacy, College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Wonkwang Oriental Medicines Research Institude) Bae, Go-Eun (Department of Oriental Pharmacy, C) Choi, Sun-Kyung Jeong, Hyun-Ja Park, Yun-Jum Kim, Hyung-Min Um, Jae-Young Hong, Seung-Heon
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제10권 제2호
발행연도
2010.1
수록면
116 - 122 (7page)

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Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-${\kappa}B$ p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.

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