지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 709 - 714 (6page)
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초록· 키워드
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Knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) of mosquitoes confer resistance to insecticides. Although insecticide resistance has been suspected to be widespread in the natural population of Aedes aegypti in Myanmar, only limited information is currently available. The overall prevalence and distribution of kdr mutations was analyzed in Ae. aegypti from Mandalay areas, Myanmar. Sequence analysis of the VGSC in Ae. aegypti from Myanmar revealed amino acid mutations at 13 and 11 positions in domains II and III of VGSC, respectively. High frequencies of S989P (68.6%), V1016G (73.5%), and F1534C (40.1%) were found in domains II and III. T1520I was also found, but the frequency was low (8.1%). The frequency of S989P/V1016G was high (55.0%), and the frequencies of V1016G/F1534C and S989P/V1016G/F1534C were also high at 30.1% and 23.5%, respectively. Novel mutations in domain II (L963Q, M976I, V977A, M994T, L995F, V996M/A, D998N, V999A, N1013D, and F1020S) and domain III (K1514R, Y1523H, V1529A, F1534L, F1537S, V1546A, F1551S, G1581D, and K1584R) were also identified. These results collectively suggest that high frequencies of kdr mutations were identified in Myanmar Ae. aegypti, indicating a high level of insecticide resistance.
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참고문헌 (36)
참고문헌 신청
Satoto TBT / 2019 / Insecticide resistance in Aedes aegypti : an impact from human urbanization / PLoS One 14:e0218079
Baruah S / 2013 / Seasonal prevalence of Aedes aegypti in urban and industrial areas of Dibrugarh district, Assam / Trop Biomed 30:434~443
Shiff C / 1998 / Vector control : methods for use by individuals and communities / Parasitol Today 14:470
World Health Organization / 2006 / Pesticides and their Application for the Control of Vectors and Pests of Public Health Importance. 6th ed / World Health Organization :9~20
Dong K / 2014 / Molecular biology of insect sodium channels and pyrethroid resistance / Insect Biochem Mol Biol 50:1~17
Baruah S / 2013 / Seasonal prevalence of Aedes aegypti in urban and industrial areas of Dibrugarh district, Assam / Trop Biomed 30:434~443
Shiff C / 1998 / Vector control : methods for use by individuals and communities / Parasitol Today 14:470
World Health Organization / 2006 / Pesticides and their Application for the Control of Vectors and Pests of Public Health Importance. 6th ed / World Health Organization :9~20
Dong K / 2014 / Molecular biology of insect sodium channels and pyrethroid resistance / Insect Biochem Mol Biol 50:1~17
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