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논문 기본 정보

자료유형
학술저널
저자정보
Gabriel Omotoso (University of Ilorin) Olajumoke Oloyede (University of Ilorin) Shakirah Lawal (University of Ilorin) Ismail Gbadamosi (University of Ilorin) Nafisat Mutholib (University of Ilorin) Fatimah Abdulsalam (University of Ilorin) Abdulkabir Bature (University of Ilorin) Abdulsalam Babalola (University of Ilorin) Busola Ayeni (University of Ilorin) Nathaniel Amedu (University of Ilorin)
저널정보
환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.35 No.4
발행연도
2020.12
수록면
19 - 31 (13page)

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This study investigated the neurotoxic effects of permethrin on the cerebellum, hippocampus and prefrontal cortex of Wistar rats and its effects on some behavioral patterns. Fifteen adult male Wistar rats were grouped into three categories: Group A received 0.1 mL normal saline (control), and Groups B and C received mixed feed with 500 ㎎/㎏ and 1,000 ㎎/㎏ of 0.6% permethrin, respectively, for 14 days. The animals were assessed for memory, anxiety and exploratory locomotion and thereafter anesthetized and transcardially perfused with normal saline and 4% paraformaldehyde (PFA). Cerebellum, hippocampus and prefrontal cortex were excised from the whole brain and processed for tissue histology, histochemistry and immunohistochemistry. Oxidative status and lipid peroxidation were also assessed using catalase, glutathione peroxidase, superoxide dismutase and malondialdehyde as biomarkers. Results revealed dose-dependent decrease in body weights but increase in cerebellar and prefrontal weights, depletion of endogenous antioxidant markers, cognitive deficits, reduced locomotor activities, degenerative changes in the microarchitecture at high doses and presence of chromatolytic cells at both low and high doses of permethrin. Astrocytes were activated while synaptophysin expression was downregulated. Permethrin causes dose-dependent neurotoxicity on the morphology, neurochemistry and oxidative status of different brain regions, and these could affect behavioral performance and other neurologic functions.

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Abstract
Introduction
Materials and Methods
Results
Discussion
Conclusions
References

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