지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.3
- 발행연도
- 2021.9
- 수록면
- 330 - 337 (8page)
이용수
초록· 키워드
오류제보하기
Colorectal cancer (CRC) is an aggressive malignancy. Critical mechanisms that support CRC progression include cell migration, invasion, metastasis, and angiogenesis, which is associated with L1 cell adhesion molecule (L1CAM) and nuclear factor-kappa B (NF-κB) signaling pathways. In this study, viability of HT-29 cells and human umbilical vein endothelial cells (HUVECs) was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays, and cell apoptosis was investigated by flow cytometry assays. HT-29 cell migration and invasion were observed by wound healing and Transwell invasion assays, respectively, and tube formation of HUVECs was observed by tubulogenesis assays. L1CAM and NF-κB protein expressions in HT-29 cells treated with onion peel extract were determined by indirect immunofluorescence. Results showed that high dose treatments of onion peel extract inhibited cell viability of both HT-29 cells and HUVECs, induced HT-29 cell apoptosis, and inhibited HT-29 cell migration and invasion. Moreover, onion peel extract decreased total HUVEC tube length and, at a concentration of 10 μg/mL, showed potential to downregulate L1CAM and NF-κB. In conclusion, onion peel extract inhibits HT-29 cell growth, migration, and invasion through suppressing pathways related to angiogenesis downstream of L1CAM-activated NF-κB.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (40)
참고문헌 신청
Aslam MS / 2014 / Side effects of chemotherapy in cancer patients and evaluation of patients opinion about starvation based differential chemotherapy / J Cancer Ther 5:817~822
Bondong S / 2012 / Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation / Ann Oncol 23:1795~1802
Carmeliet P / 2005 / VEGF as a key mediator of angiogenesis in cancer / Oncology 69:4~10
Rita Celano / 2021 / Onion Peel: Turning a Food Waste into a Resource / Antioxidants 10(2):304
Chen J / 2018 / L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer / Exp Ther Med 15:2792~2797
Bondong S / 2012 / Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation / Ann Oncol 23:1795~1802
Carmeliet P / 2005 / VEGF as a key mediator of angiogenesis in cancer / Oncology 69:4~10
Rita Celano / 2021 / Onion Peel: Turning a Food Waste into a Resource / Antioxidants 10(2):304
Chen J / 2018 / L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer / Exp Ther Med 15:2792~2797
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Walnut Improves Particulate Matter (PM)2.5-Induced Neurotoxicity in HT22 Cells
한국식품영양과학회 학술대회발표집
2021 .10
-
야관문의 에탄올 추출물에 의한 대장암세포의 성장억제 및 세포사멸유도
한국식품영양과학회지
2016 .06
-
함유황 다당체 Fucoidan의 인체 대장암세포(HT-29) 사멸과 Apoptosis에 미치는 영향
한국식품영양학회지
2022 .06
-
Curcuma longa L. Extract and Curcumin Derivatives Inhibit Inflammation and Apoptosis through the Expression of HO-1 in HT-29 Cells
한국식품영양과학회 학술대회발표집
2024 .10
-
Indole-6-carboxaldehyde inhibits the expression of PMA-induced metalloproteinase matrix (MMP)-9 and invasion of HT1080 human fibrosarcoma cell through suppressing phosphorylation of MAPK and NF-kB
한국수산과학회 양식분과 학술대회
2017 .05
-
Gamma-irradiated Chrysin Induces Apoptosis in HT-29 Colon Cancer Cells
한국식품영양과학회 학술대회발표집
2016 .10
-
In Vitro Antiproliferative and Apoptosis Inducing Activity of Bibimbap on HT-29 Human Colorectal Adenocarcinoma Cells
한국식품영양학회지
2022 .12
-
Effect of different operating conditions of chestnut peeling machine on peeling properties/peeling efficiency
한국식품영양과학회 학술대회발표집
2023 .10
-
Induction of ROS-Mediated Cell Cycle Arrest and Apoptosis by Ethanol Extract of Inula japonica Flowers in HT-1080 Human Fibrosarcoma Cells
한국식품영양과학회 학술대회발표집
2017 .10
-
렌즈콩(Lens culinaris) 추출물이 HepG2 인간 간암 세포에서 Proteasome 활성과 Nuclear Factor κB 활성화에 미치는 영향
한국식품영양학회지
2019 .01
-
Anticancer Effects of Black Soybean Doenjang in HT-29 Human Colon Cancer Cells
한국식품영양과학회 학술대회발표집
2015 .08
-
EFFECT OF BROWN ALGAE EXTRACT ON MMP-2 AND MMP-9 EXPRESSION IN HT-1080 CELLS
한국수산과학회 양식분과 학술대회
2015 .05
-
Gliotoxin from the marine fungus Aspergillus fumigatus induces apoptosis in HT1080 fibrosarcoma cells by downregulating NF-κB
Fisheries and Aquatic Sciences
2016 .01
-
Extracts from Cnidium monnieri (L.) Cusson induces Apoptosis and Cell Cycle Arrest through Regulating Akt/GSK-3β Signaling Pathways and Cyclooxygenase-2 expression in HT-29 Colon Cancer Cells
한국식품영양과학회 학술대회발표집
2016 .10
-
Neuroprotective Effect of Mulberry Extract on Glutamate-induced Oxidative Stress in Mouse Hippocampal HT-22 cells
한국식품영양과학회 학술대회발표집
2015 .08
-
Scientific evidence of astragalus extract mixture HT042 in child height growth
한국식품영양과학회 학술대회발표집
2023 .10
-
Development of Functional Substances to Promote Child Growth: Focusing on Astragalus Extract Mixture HT042
한국식품영양과학회 학술대회발표집
2022 .10
-
Antiproliferative Effects of Lespedeza cuneata G. Don in Human Colorectal HT-29 Cells
한국식품영양과학회 학술대회발표집
2015 .08
-
Inhibitory effect of dieckol on CoCl₂-induced epithelial-to-mesenchymal transition of human colorectal cancer cell HT29
한국수산과학회 양식분과 학술대회
2015 .10
-
Neuroprotective effect of Aronia melanocarpa extract against glutamate-induced oxidative stress on HT22 cells
한국식품영양과학회 학술대회발표집
2016 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Predictive modeling algorithms for liver metastasis in colorectal cancer: A systematic review of the current literature
Isaac Seow-En
,
Ye Xin Koh
,
Yun Zhao
외 7명
Annals of Hepato-Biliary-Pancreatic Surgery
2024
.02
Exploring the role of copine 1 in human colorectal cancer: investigating its association with tumorigenesis andmetastasis
Jin-Kwon Lee
,
Seung-Jun Lee
,
Young-Sool Hah
외 11명
Annals of Surgical Treatment and Research
2023
.12
Totally laparoscopic central bisectionectomy for colorectal cancer liver metastasis using indocyanine green fluorescence imaging
Youngmok PARK
,
Jae
,
i KIM
외 2명
Annals of Hepato-Biliary-Pancreatic Surgery
2021
.12
[Colorectal] Risk Factors Associated with Survival after Metastasectomy in Patients with Pulmonary Metastasis from Colorectal Cancer: A Single Center Experience
Seung Ah Lee
,
Dae Hee Pyo
,
Seung Hyeon Yun
외 7명
대한외과학회 학술대회 초록집
2022
.11
The Effect of Para-aortic Lymph Node Dissection for Colorectal Cancer Patients with Other Distant Metastasis
Jun Woo Bong
대한외과학회 학술대회 초록집
2022
.11
최근 본 자료
댓글(0)
0