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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 186 - 186 (1page)
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Spondyloarthritis (SpA) is systemic inflammatory arthritis which is mainly mediated by interleukin (IL)-17. Vitronectin-derived bioactive peptide, VnP-16, has shown anti-osteoporotic effects via β1 integrin and αvβ3 integrin signal. SpA also has increased risk of osteoporosis, and we aimed to investigate preventive effects of VnP-16 in curdlan-induced SpA mice. The SpA mice model was induced by curdlan in SKG ZAP-70W163C mice. Treatment with vehicle, celecoxib, VnP-16, or VnP-16 with celecoxib was performed to SpA mice. Clinical score, arthritis score, spondylitis scores, and proinflammatory cytokine expression of spine via immunohistochemical stain were evaluated. Type 17 helper T cell (Th17) and regulatory T cell (Treg) differentiation in spleen were measure by flow cytometry, and confocal stain in spine. Clinical score was significantly suppressed in VnP16 + celecoxib group. Arthritis and spondylitis scores of histology were significantly decreased in ... 전체 초록 보기
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