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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 374 - 379 (6page)
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Tetranectin (TN), an adipogenic serum protein, enhances adipocyte differentiation, however, its functional mechanism has yet to be elucidated. In the present study, we investigated the adipogenic function of TN by using medium containing TN-depleted fetal bovine serum (TN-del-FBS) and recombinant mouse TN (mTN). The adipocyte differentiation of 3T3-L1 cells was significantly enhanced by mTN supplementation essentially at differentiation induction, which indicated a potential role of the protein in the early differentiation phase. The adipogenic effect of mTN was more significant with insulin in the differentiation induction cocktail, implicating their close functional relationship. mTN enhanced not only the proliferation of growing cells, but also mitotic clonal expansion (MCE) that is a prerequisite for adipocyte differentiation in the early phase. Consistently, mTN increased the phosphorylation of ERK in the early phase of adipocyte differentiation. Results of this study demonstrate that the adipogenic function of mTN is mediated by enhancing MCE via ERK signaling.
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참고문헌 (24)
참고문헌 신청
Clemmensen I / 1986 / Purification and characterization of a novel, oligomeric, plasminogen kringle 4 binding protein from human plasma : tetranectin / Eur J Biochem 156:327~333
Westergaard UB / 2003 / Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator / Eur J Biochem 270:1850~1854
Tuxen MK / 1995 / Tumor markers in the management of patients with ovarian cancer / Cancer Treat Rev 21:215~245
Hogdall CK / 1994 / Tetranectin, a plasma and tissue protein--a prognostic marker of breast and ovarian cancer / Ugeskr Laeger 156:6190~6195
Wewer UM / 1992 / Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer / Lab Invest 67:253~262
Westergaard UB / 2003 / Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator / Eur J Biochem 270:1850~1854
Tuxen MK / 1995 / Tumor markers in the management of patients with ovarian cancer / Cancer Treat Rev 21:215~245
Hogdall CK / 1994 / Tetranectin, a plasma and tissue protein--a prognostic marker of breast and ovarian cancer / Ugeskr Laeger 156:6190~6195
Wewer UM / 1992 / Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer / Lab Invest 67:253~262
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