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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 941 - 950 (10page)
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초록· 키워드
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Objective This study aimed to investigate the morphometric differences in the corpus callosum between patients with major depressive disorder (MDD) and healthy controls and analyze their relationship to gray matter changes.Methods Twenty female MDD patients and 21 healthy controls (HCs) were included in the study. To identify the difference in the regional gray matter concentration (GMC), VBM was performed with T1 magnetic resonance imaging. The shape analysis of the corpus callosum was processed. Diffusion tensor imaging (DTI) fiber-tracking was performed to identify the regional tract pathways in the damaged corpus callosal areas.Results In the shape analysis, regional shape contractions in the rostrum and splenium were found in the MDD patients. VBM analysis showed a significantly lower white matter concentration in the genu and splenium, and a significantly lower GMC in the frontal, limbic, insular, and temporal regions of the MDD patients compared to the HCs. In DTI fiber-tracking, the fibers crossing the damaged areas of the genu, rostrum, and splenium were anatomically connected to the areas of lower GMC in MDD patients.Conclusion These findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum.
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등록된 정보가 없습니다.
참고문헌 (84)
참고문헌 신청
Fava M / 2000 / Major depressive disorder / Neuron 28:335~341
Hasin DS / 2018 / Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States / JAMA Psychiatry 75:336~346
Kessler RC / 2003 / The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R) / JAMA 289:3095~3105
Baldessarini RJ / 2017 / Morbidity in depressive disorders / Psychother Psychosom 86:65~72
Drevets WC / 2008 / Brain structural and functional abnormalities in mood disorders : implications for neurocircuitry models of depression / Brain Struct Funct 213:93~118
Hasin DS / 2018 / Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States / JAMA Psychiatry 75:336~346
Kessler RC / 2003 / The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R) / JAMA 289:3095~3105
Baldessarini RJ / 2017 / Morbidity in depressive disorders / Psychother Psychosom 86:65~72
Drevets WC / 2008 / Brain structural and functional abnormalities in mood disorders : implications for neurocircuitry models of depression / Brain Struct Funct 213:93~118
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