Baseline Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT Predict Outcomes in T-Cell Lymphoblastic Lymphoma

Xiaoyan Feng; Xin Wen; Ling Li; Zhenchang Sun; Xin Li; Lei Zhang; Jingjing Wu; Xiaorui Fu; Xinhua Wang; Hui Yu; Xinran Ma; Xudong Zhang; Xinli Xie; Xingmin Han; Mingzhi Zhang

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자료유형: 학술저널

저자정보: Xiaoyan Feng (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xin Wen (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Ling Li (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Zhenchang Sun (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xin Li (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Lei Zhang (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Jingjing Wu (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xiaorui Fu (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xinhua Wang (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Hui Yu (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xinran Ma (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xudong Zhang (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xinli Xie (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Xingmin Han (The First Affiliated Hospital of Zhengzhou University Zhengzhou China) Mingzhi Zhang (The First Affiliated Hospital of Zhengzhou University Zhengzhou China)

저널정보: 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제53권 제3호

발행연도: 2021.1

수록면: 837 - 846 (10page)

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Purpose There is no optimal prognostic model for T-cell lymphoblastic lymphoma (T-LBL). Here, we discussed the predictive value of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured on 18F-fluorodeoxyglucose positron emission tomography?computed tomography (PET-CT) in T-LBL.Materials and Methods Thirty-seven treatment naive T-LBL patients with PET-CT scans were enrolled. TMTV was obtained using the 41% maximum standardized uptake value (SUVmax) threshold method, and TLG was measured as metabolic tumor volume multiplied by the mean SUV. Progression-free survival (PFS) and overall survival (OS) were analyzed by Kaplan-Meier curves and compared by the log-rank test.Results The optimal cutoff values for SUVmax, TMTV, and TLG were 12.7, 302 cm3, and 890, respectively. A high SUVmax, TMTV, and TLG indicated a shorten PFS and OS. On multivariable analysis, TMTV ≥ 302 cm3, and central nervous system (CNS) involvement predicted inferior PFS, while high SUVmax, TLG and CNS involvement were associated with worse OS. Subsequently, we generated a risk model comprising high SUVmax, TMTV or TLG and CNS involvement, which stratified the population into three risk groups, which had significantly different median PFS of not reached, 14 months, and 7 months for low-risk group, mediate-risk group, and high-risk group, respectively (p < 0.001). Median OS were not reached, 27 months, and 13 months, respectively (p < 0.001).Conclusion Baseline SUVmax, TMTV, and TLG measured on PET-CT are strong predictors of worse outcome in T-LBL. A risk model integrating these three parameters with CNS involvement identifies patients at high risk of disease progression.

#Total metabolic tumor volume #Total lesion glycolysis #Positron emission tomography?computed tomography #T-cell lymphoblastic lymphoma #Prognosis

참고문헌 (26)

참고문헌 신청

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Barrington SF / 2014 / Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group / J Clin Oncol 32:3048~3058

Kim TM / 2013 / Total lesion glycolysis in positron emission tomography is a better predictor of outcome than the International Prognostic Index for patients with diffuse large B cell lymphoma / Cancer 119:1195~1202

Sasanelli M / 2014 / Pretherapy metabolic tumour volume is an independent predictor of outcome in patients with diffuse large B-cell lymphoma / Eur J Nucl Med Mol Imaging 41:2017~2022

Ceriani L / 2015 / Utility of baseline 18FDG-PET/CT functional parameters in defining prognosis of primary mediastinal(thymic)large B-cell lymphoma / Blood 126:950~956

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