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자료유형
학술저널
저자정보
최용준 (연세대학교) 김송이 (연세대학교) 박무석 (연세대학교) 이진구 (연세대학교) 백효채 (연세대학교) 이상훈 (연세대학교)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제61권 제11호
발행연도
2020.1
수록면
958 - 964 (7page)

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Purpose: Recent history of malignancy without 5-year disease-free interval is an absolute contraindication for lung transplantation(LTx). However, in rare cases, lung cancer may be incidentally diagnosed in the explanted lung of recipients. We evaluatedthe prevalence, 5-year survival, and prognosis of incidental lung cancer after LTx. Materials and Methods: Medical records of patients who underwent LTx at Severance Hospital between January 1, 2012 and June30, 2019 were reviewed. Patients with incidental lung cancer were included, and those with histologically proven pre-transplantlung cancer were excluded. Results: Of the 247 patients who underwent LTx, 6 (2.4%) were diagnosed with incidental lung cancer. Interstitial lung disease(ILD) was the underlying lung disease in all patients. The median interval from the last preoperative computed tomography (CT)screening to LTx was 26 days. The most common histological type of incidental lung cancer was adenocarcinoma (n=4, 66.7%). All Stage IV cases were misdiagnosed as fibrosis on preoperative chest CT. Patients with incidental lung cancer showed lower5-year survival than those without malignancy (median survival: 8.5 months vs. not reached, p=0.047, respectively). Patients withStage III or IV demonstrated lower 5-year survival than those with Stage I or II and those without malignancy (median survival: 5months, 19 months, and not reached, respectively, p=0.011). Conclusion: Multidisciplinary preoperative screening and serial imaging studies within short intervals are required to differentiatelung malignancy from fibrotic foci. Furthermore, active pathologic examination of suspicious lung lesions is required in patientsat high risk for lung cancer.

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