지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 149 - 158 (10page)
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초록· 키워드
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Purpose: We investigated whether antineutrophil cytoplasmic antibody (ANCA) positivity is associated with vascular manifestationsat diagnosis of Behcet’s disease (BD) and poor outcomes during follow-up. Materials and Methods: We retrospectively reviewed the medical records of 1060 patients with BD. Among them, 808 patientscould be diagnosed with BD based on the revised version of the International Criteria for Behcet’s Disease (ICBD) in 2014 (2014ICBD criteria) and 588 patients could be diagnosed with BD based on the International Study Group (ISG) criteria proposed in1990 (1990 ISG criteria). We examined the sites and patterns of vascular involvement in the BD patients at diagnosis and evaluatedadverse outcomes during follow up, such as all-cause mortality, acute coronary syndrome, and deep vein thrombosis. Results: Among the 808 patients with BD based on the 2014 ICBD criteria, the rate of ANCA positivity at diagnosis was 2.2%. ANCA-positive BD patients exhibited a higher frequency of overall vascular manifestations (22.2% vs. 6.1%) and higher frequenciesof vascular involvement in the upper extremities and visceral arteries than ANCA-negative BD patients (5.6% vs. 0.1% and 5.6%vs. 0.1%). Among the 588 BD patients based on the 1990 ISG criteria, similarly, ANCA-positive BD patients exhibited a higher frequencyof vascular manifestations than ANCA-negative BD patients. ANCA positivity, however, did not seem to be associatedwith poor outcomes in BD patients during follow up. Conclusion: ANCA positivity in BD patients was found to be associated with cross-sectional vascular involvement in the upperextremities and visceral arteries at diagnosis but was not predictive of poor outcomes during follow-up.
목차
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참고문헌 (18)
참고문헌 신청
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
Greco A / 2018 / Behçet’s disease : new insights into pathophysiology, clinical features and treatment options / Autoimmun Rev 17:567~575
Ambrose NL / 2013 / Differential diagnosis and management of Behçet syndrome / Nat Rev Rheumatol 9:79~89
International Study Group for Behçet’s Disease / 1990 / Criteria for diagnosis of Behçet’s disease / Lancet 335:1078~1080
International Team for the Revision of the International Criteria for Behçet’s Disease (ITR-ICBD) / 2014 / The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria / J Eur Acad Dermatol Venereol 28:338~347
Greco A / 2018 / Behçet’s disease : new insights into pathophysiology, clinical features and treatment options / Autoimmun Rev 17:567~575
Ambrose NL / 2013 / Differential diagnosis and management of Behçet syndrome / Nat Rev Rheumatol 9:79~89
International Study Group for Behçet’s Disease / 1990 / Criteria for diagnosis of Behçet’s disease / Lancet 335:1078~1080
International Team for the Revision of the International Criteria for Behçet’s Disease (ITR-ICBD) / 2014 / The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria / J Eur Acad Dermatol Venereol 28:338~347
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