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논문 기본 정보

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학술저널
저자정보
Yoon Hyuk (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea) Shim Hyun Ik (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea) Seol Mijin (R&D Center BioBankHealing Inc. Seongnam Korea) Shin Cheol Min (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam KoreaDepartment) Park Young Soo (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea) Kim Nayoung (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam KoreaDepartment) Lee Dong Ho (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam KoreaR&D Ce)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제1호
발행연도
2021.1
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61 - 69 (9page)

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Background/Aims: The aim of this study was to evaluate factors related to outcomes of fecal microbiota transplantation (FMT) in patients with Clostridioides difficile infection (CDI) and viability of frozen stock for FMT. Methods: Clinical data of patients who had received FMT for CDI were prospectively collected. Next-generation 16S rRNA gene sequencing of bacteria was performed from donors’ and recipients’ stool. Colony-forming units (CFUs) of cultures from frozen stock solutions for FMT were measured at 0, 4, 8, 12, 24, 48 weeks after preparation of the solutions. Results: In total, 25 FMT procedures were performed in 20 cases (14 fresh and 11 frozen FMT). Forty-five percent of cases involved fulminant CDI. The overall success rate was 55% after the 1st FMT and 75% after the 2nd FMT. The success rate was significantly higher in partially treated CDI than in refractory CDI (100% vs 71.4%; p=0.001). In successful cases only, the decrease in alpha-diversity in the recipient stool microbiomes was recovered after FMT to a level similar to that in donor stools. There was a significant difference in the microbiome composition in pre-FMT recipients’ stool between successful and failed cases (p=0.001). The CFUs of frozen solution for FMT did not decrease for 48 weeks in both aerobic and anaerobic cultures. Conclusions: FMT is highly effective in partially treated CDI but not in refractory CDI. The microbiome differs between failed and successful cases. Frozen stock for FMT is viable up to 48 weeks.
#Clostridioides difficile infection #Clostridium difficile infection #Fecal microbiota transplantation

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참고문헌 (29)

참고문헌 신청
McDonald LC / 2018 / Clinical practice guidelines for Clostridium difficile infection in adults and children : 2017 update by the Infectious Diseases Society of America(IDSA)and Society for Healthcare Epidemiology of America(SHEA) / Clin Infect Dis 66:987~994 google schola Jung Hoon Song / 2019 / Recurrent Clostridium difficile Infection: Risk Factors, Treatment, and Prevention / Gut and Liver 13(1):16~24 dbpia Quraishi MN / 2017 / Systematic review with meta-analysis : the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection / Aliment Pharmacol Ther 46:479~493 google schola Mullish BH / 2018 / The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications : joint British Society of Gastroenterology(BSG)and Healthcare Infection Society(HIS)guidelines / Gut 67:1920~1941 google schola Surawicz CM / 2013 / Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections / Am J Gastroenterol 108:478~498 google schola

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